All XRAYs



Relevance: High
Most relevant for: People with advanced or metastatic breast cancer with a PIK3CA tumor mutation.
Study: New FDA approval of Itovebi, a drug that may improve treatment for certain advanced or metastatic breast cancers
About one-third of hormone receptor-positive (HR-positive), HER2-negative metastatic breast cancers have a PIK3CA tumor mutation that can increase cancer growth and lead to treatment resistance. A new targeted therapy, Itovebi (inavolisib), improved patient outcomes when combined with standard treatment. This led to the recent FDA approval of the drug. (Posted 7/3/25)
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Relevance: Medium-High
Most relevant for: People of Hispanic ancestry who have pancreatic cancer or have a family history of cancer
Study: Hereditary pancreatic cancer among people of Hispanic ancestry in Mexico
This study looks at people of Mexican ancestry who have pancreatic cancer to identify mutations linked to hereditary cancer. Knowledge of a hereditary cancer mutation can inform patients and their family members about the need for additional surveillance or different treatment options. Access to genetic testing in Mexico is more limited than in the United States. This study emphasizes the importance of genetic testing for inherited cancer risk in pancreatic cancer patients in Mexico. (posted 6/25/25)
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Relevance: High
Most relevant for: People with HR-positive metastatic breast cancer
Study: Enhertu shows promising results for HER2-low and HER2-ultralow metastatic breast cancer
Recent study results show that a new targeted treatment works better than standard chemotherapy for people with metastatic hormone receptor-positive breast cancers with low or ultralow HER2 status. (Posted 5/15/25)
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Relevance: High
Most relevant for: People with hereditary pancreatic cancer risk or strong family history of pancreatic cancer
Study: Impact of mental healthcare among those with increased pancreatic cancer risk
Pancreatic cancer is often aggressive and diagnosed at a late stage, which can lead to uncertainty and fear. For those at risk due to a genetic mutation or family history, access to surveillance and mental health support is essential to help manage the emotional impact. (Posted 5/12/25)
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Relevance: High
Most relevant for: People with unresectable or metastatic colorectal cancer that is MSI-High or dMMR
Study: Two immunotherapy drugs are better than one for some metastatic colorectal cancers
Combining two immunotherapy drugs is a more effective treatment for certain metastatic colorectal cancers than using either treatment drug alone. Used together, Opdivo (nivolumab) plus Yervoy (ipilimumab) slowed cancer growth in MSI-High metastatic colorectal cancers, a type of colorectal cancer often found in Lynch syndrome. The FDA approved this combined treatment for MSI-High metastatic colorectal cancer after progression with chemotherapy. (Posted 4/30/25)
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Relevance: Medium
Most relevant for: People with multiple myeloma or who have families with multiple myeloma
Study: Hereditary cancer mutations among people with multiple myeloma
People with multiple myeloma who have inherited gene mutations are more likely to have had another cancer previously and may respond better to certain treatments than people with multiple myeloma who do not have inherited mutations. Individuals with an inherited BRCA1 and BRCA2 mutation may have a slightly increased risk for multiple myeloma, but more research is needed to confirm this. (Posted 4/23/25)
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Relevance: Medium-High
Most relevant for: People with colorectal cancer or at risk of colorectal cancer
Update: News from the FDA: Colorectal cancer screening and treatment
This XRAY review is a summary of FDA colorectal cancer (CRC) updates in the last year, including education regarding CRC screening, three treatment drugs targeting different types of CRC and two colorectal screening tests. (Posted 4/16/25)
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Relevance: Medium-High
Most relevant for: Premenopausal women before or during early breast cancer treatment
Update: Ovarian suppression may reduce breast cancer recurrence
Ovarian suppression—blocking estrogen production in the ovaries—can improve breast cancer outcomes in premenopausal women. This review provides information about ovarian suppression and describes who might benefit. (Posted 3/6/25)
Este artículo está disponible en español.



Relevance: Medium-High
Most relevant for: Young women with breast cancer concerned about survivorship issues
Topic: Addressing the needs of young adults with breast cancer
This update addresses common concerns faced by young adults with breast cancer, particularly fertility and childbearing, psychosocial health and treatment-related side effects. (Posted 2/28/25)
Este artículo está disponible en español.
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Relevance: Medium-High
Most relevant for: Men with West African ancestry
Study: Neighborhood affects prostate cancer risk in men of West African ancestry
Black men of West African genetic ancestry have a much higher risk of developing prostate cancer than men of other races. The risk is even greater when they live in deprived or disadvantaged neighborhoods. (Posted 2/26/25)
Este artículo está disponible en español.
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