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Genes linked to hereditary cancer
About 1 out of 10 cancers is caused by an . The genes listed below have been linked to an increased risk for hereditary cancer. Note: this is not a complete list.
* More research is needed to confirm a link between cancer and an in these genes.
Genetic testing results may affect cancer treatment and prognosis
- In addition to increasing lifetime risk for cancer, , (and possibly other genes) have been linked to more aggressive, disease.
- People with mCRPC who test positive for an may benefit from targeted or to treat their cancer.
FORCE offers many peer support programs for people with inherited mutations.
- Our Message Boards allow people to connect with others who share their situation. Once registered, you can post on the Diagnosed With Cancer board to connect with other people who have been diagnosed.
- Our Peer Navigation Program will match you with a volunteer who shares your mutation and situation.
- Our moderated, private Facebook group allows you to connect with other community members 24/7.
- Check out our virtual and in-person support meeting calendar.
- Join one of our Zoom community group meetings.
The National Comprehensive Cancer Network guidelines recommend genetic counseling and testing for the following people with cancer who have:
- a tumor test result that suggests an inherited mutation
- for example, a tumor with a , or mutation may indicate an in one of those genes
- a blood relative who tested positive for an in a gene linked to cancer
- cancer diagnosed at any age
- cancer that has spread to the
- localized cancer (hasn’t spread beyond the ) that is considered very high-risk or high-risk
- intermediate-risk cancer with intraductal or cribriform features listed on the
- a diagnosis of male breast cancer
- Eastern European (Ashkenazi) Jewish ancestry
- one or more relatives with:
- breast, colorectal or endometrial cancer diagnosed at age 50 or younger
- male breast cancer, triple negative breast cancer, ovarian cancer or pancreatic cancer at any age
- , regional, very-high-risk, or high-risk cancer at any age
- one or more close relatives with cancer diagnosed at age 60 or younger
- three or more relatives on the same side of the family with biliary tract, breast, colorectal, endometrial, glioblastoma, or other cancers
Speak with a genetic counselor if you have questions about whether you meet guidelines for genetic testing.
The following clinical trials include genetic counseling and testing.
- NCT02620852: WISDOM Study: Women Informed to Screen Depending on Measures of Risk offers women ages 40-74 the opportunity to undergo risk assessment and genetic testing in order to determine the best breast screening options based on their situation.
- NCT05562778: Chatbot to maximize genetic risk assessment. Researchers are testing whether a mobile health platform, known as a "chatbot" can improve rates of genetic testing among Medicaid patients with an elevated risk having an .
- NCT05427240: eHealth Delivery Alternative for Cancer Genetic Testing for (eReach2). This study will look at the effectiveness of offering web-based options for pre/post-test genetic counseling to provide equal or improved timely uptake of genetic services and testing.
- NCT05694559: Connecting Black Families in Houston, Texas to Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics. This study will provide genetic testing to 150 Black individuals and families and provide genetic counseling and risk reduction resources to individuals with a mutation linked to increased cancer risk.
Other genetic counseling or testing studies may be found here.