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Risk Management Guidelines

Learn about the steps that people at high risk for cancer can take to manage their risk and protect their health.

NCCN Guidelines for Men and Women with CDH1 Mutations

The following are recommendations for women and men with mutations in CDH1

NCCN Guidelines for Women with Mutations in CDH1

Breast cancer screening:

  • Annual mammogram and consider annual breast MRI with contrast or mammogram beginning at age 30 (or younger if family history of breast cancer before age 25)

Breast cancer risk reduction:

  • Discussion of risk-reducing mastectomy based on family history of breast cancer

NCCN Guidelines for Men and Women with Mutations in CDH1

Gastric cancer risk management:

  • Risk-reducing gastrectomy (removal of the stomach) is recommended between the age of 18 and 40 for people with CDH1 mutations
  • Upper endoscopy and multiple random biopsies every 6-12 months for people who do not undergo gastrectomy

Updated 01/06/2018

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