No one should face hereditary cancer alone.

Thinking about cancer or dealing with cancer risk can be scary or overwhelming, but we believe that receiving information and resources is comforting, empowering, and lifesaving.

Hereditary Cancer Info > Hereditary Cancer > Genes Associated with Hereditary Cancers

| More

Toggle Menu

Genes Associated with Hereditary Cancers

Learn about genes and cancer, signs of hereditary cancer, genetic counseling, types of genetic tests and what results mean for you and your family.

CDH1 (Hereditary diffuse gastric cancer syndrome)

Inherited mutations in the CDH1 gene are associated with hereditary diffuse gastric cancer syndrome, which is known to increase the risk of certain cancers, including:

  • stomach cancer (up to 80% lifetime risk)
  • lobular breast cancer in women (up to 52% lifetime risk)

People with mutations in CDH1 tend to develop cancer at a younger age than people with average cancer risk.

National guidelines for managing cancer risk in people with CDH1 mutations recommend:

  • heightened screening for breast cancer in women
  • discussing the option of risk-reducing mastectomy (surgical removal of breast tissue)
  • endoscopy to screen for stomach cancer
  • risk-reducing gastrectomy (surgical removal of stomach) 

A genetics expert can look at your personal and family medical history and see if it is consistent with hereditary diffuse gastric cancer syndrome syndrome and order testing if appropriate. 


updated 04/09/15

FORCE:Facing Our Risk of Cancer Empowered