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Inherited mutations in the CDH1 gene are associated with hereditary diffuse gastric cancer syndrome, which is known to increase the risk of certain cancers, including:
People with mutations in CDH1 tend to develop cancer at a younger age than people with average cancer risk.
National guidelines for managing cancer risk in people with CDH1 mutations recommend:
A genetics expert can look at your personal and family medical history and see if it is consistent with hereditary diffuse gastric cancer syndrome syndrome and order testing if appropriate.