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PARP Inhibitor Therapy

There are many options for treating hereditary cancers. Choice of treatment can be personalized based on cancer type, stage and genetics.

PARP inhibitors for breast cancer

PARP inhibitors for metastatic breast cancer

Lynparza is a PARP inhibitor that is FDA approved for treating metastatic breast cancer caused by a BRCA mutation. Additionally, research using other PARP inhibitors for metastatic hereditary breast cancer have been completed, and FDA approval for additional PARP inhibitors is expected soon. Based on clinical trial results, the National Comprehensive Cancer Network (NCCN) recently added Lynparza as a preferred treatment for women with advanced breast cancer and a BRCA mutation. 

Talazoparib is a PARP inhibitor that has not yet received FDA approval and is being studied in clinical trials. A large clinical trial known as the EMBRACA trial studied talazoparib for patients with metastatic breast cancer and a BRCA1 or BRCA2 mutation. Results showed that patients receiving talazoparib had on average 8.6 months of progression free survival compared to 5.6 months for patients receiving chemotherapy. 

Based on these results, experts are hopeful that Talazoparib will receive FDA approval for treating metastatic breast cancer caused by a BRCA mutation.

PARP inhibitors in breast cancer clinical trials 

Research is now also looking at PARP inhibitor effectiveness in additional settings including:

  • patients with metastatic breast cancer who have other inherited mutations beyond BRCA1 and BRCA2, such as ATM and PALB2
  • patients with triple-negative metastatic breast cancer
  • PARP inhibitors in combination with other agents, such as drugs that shrink blood supply and immunotherapies.

You can look for research studies enrolling patients with breast cancer by visiting FORCE's Research Study Search Tool.


Updated 01/12/2018

FORCE:Facing Our Risk of Cancer Empowered