BRCA1 Gene Mutations
Information for People with an Inherited BRCA1 Mutation
What cancers are associated with a mutation?
People with an in BRCA1 have an increased risk for the following cancers:
- breast
- ovarian
- pancreatic
- other cancers
What can people do if they are BRCA1 mutation positive?
People with a BRCA1 mutation have options for screening, prevention and treatment of . There are expert guidelines and clinical trials that focus on:
- screening and early detection
- risk-reduction
- treatment
There may be other medical concerns, including a rare childhood disease known as Fanconi anemia which can happen in people who inherit a mutation in both copies of their BRCA1 gene.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on BRCA1 Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited BRCA1 mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a BRCA1 mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
Tumor biomarker testing and genetic testing can provide additional clues about which treatments may work best for your cancer. People who test positive for a BRCA1 mutation may have additional treatment or clinical trial options available to them.
Other Considerations
People who inherit a mutation in both copies of their BRCA1 gene—one from each parent—have a rare disease known as Fanconi anemia. Learn additional information about inherited BRCA1 mutations.
More Resources
Participate in Prevention Research
The screening and prevention studies below are enrolling people with BRCA1 mutations. To search for more studies, visit our Search and Enroll Tool.
Participate in Treatment Research
The treatment studies below are enrolling people with BRCA1 mutations. To search for more studies, visit our Search and Enroll Tool.
