Initial results from the IMPACT trial show that PSA testing to screen for prostate cancer in people with Lynch syndrome can detect aggressive early prostate cancers. These findings support the use of PSA screening in men with Lynch syndrome, particularly men with an inherited mutation in an MSH2 or MSH6 gene. (Posted 11/10/22)
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The NCCN suggests that individuals with inherited mutations linked to Lynch syndrome talk with their doctor about the benefits and risks of PSA screening beginning at age 40. Those people who elect to have PSA screening should consider having yearly screenings rather than every other year.
The following are studies looking at ways to screen for prostate cancer in people at high risk:
NCT05608694: MRI Screening in Men at High Risk of Developing Prostate Cancer. The purpose of this study is to determine whether or not Magnetic Resonance Images (MRI) will identify high-grade cancers earlier and more frequently in men at high risk of developing prostate cancer.
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.