Personalized vaccines may help pancreatic cancer treatment
https://www.facingourrisk.org/XRAY/personalized-vaccine-pancreatic-cancer-treatment
Full article: https://doi.org/10.1038/s41586-023-06063-y
Pancreatic cancer is usually diagnosed at a late stage when patients have few treatment options. Early study results showed that a pancreatic cancer vaccine delayed the return of cancer for nearly half of the participants. (Posted 8/29/23)
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Questions To Ask Your Health Care Provider
- Do I qualify for any pancreatic cancer vaccine clinical trials?
- How do I get tumor testing to look for specific treatment options?
- Should I consider having genetic testing for an inherited mutation?
- What side effects are associated with my cancer treatment(s)?
Open Clinical Trials
The following treatment studies are enrolling people diagnosed with pancreatic cancer.
- NCT07252232: Using the Drug Daraxonrasib in Surgically Removed Pancreatic Cancer (RASolute 304). This study is testing whether a new drug, Daraxonrasib (RMC-6236), helps prevent pancreatic cancer from returning after surgery and chemotherapy.
- NCT07491445: Comparing Daraxonrasib With or Without Chemotherapy to Chemotherapy Alone for First-Line Treatment of Metastatic Pancreatic Cancer (Rasolute 303). This study is testing a new targeted drug called daraxonrasib to see if it helps people with metastatic pancreatic cancer live longer or keep their cancer from growing longer than standard chemotherapy alone.
- NCT06411691: KRAS-Targeted Vaccine Combined With Targeted Therapy for Patients With Stage IV MMR-p Colorectal Cancer or Pancreatic Ductal Adenocarcinoma. This study will test the efficacy and immune response to a KRAS vaccine combined with immunotherapy for unresectable or metastatic mismatch repair-proficient (MMR-p) colorectal cancer (mCRC) or unresectable or metastatic MMR-p pancreatic ductal adenocarcinoma (PDAC) patients with measurable disease following first-line chemotherapy.
- NCT06782932: Comparing Neoadjuvant/​Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic Cancer. The purpose of this study is to determine the best dose of the drug AGEN2373 that is safe when given in combination with immunotherapy and Pancreatic GVAX vaccine and evaluate the safety and activity of balstilimab and AGEN2373 in combination with different vaccines in surgically resectable pancreatic adenocarcinoma.
- NCT04858334: Olaparib or Placebo in Patients with Surgically Removed Pancreatic Cancer who have a BRCA1, BRCA2 or PALB2 Mutation (APOLLO). This study compares the usual approach (observation) to treatment for one year with olaparib in patients with a BRCA1, BRCA2 or PALB2 mutation.
- NCT05932862: Study of a New InvestigationaI Inhibitor to Treat People with Advanced Solid Tumors. The study will test if an investigational treatment, XL309, is safe and works when used alone or in combination with a PARP inhibitor to treat people with advanced cancers, including pancreatic cancer.
- NCT04150042: SHARON: A Clinical Trial for Metastatic Cancer With an Inherited BRCA or PALB2 Mutation Using Chemotherapy and Patients’ Own Stem Cells. This study looks at whether melphalan, BCNU, vitamin B12b and vitamin C followed by autologous (self) bone marrow stem cell infusion is safe and effective for treating patients with advanced pancreatic cancer or stage 4, HER2-negative breast cancer for people with a BRCA1, BRCA2 or PALB2 inherited mutation.
Other clinical trials for people with pancreatic cancer can be found here.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.