Metastatic prostate cancer cases increased as screening use declined

Open Clinical Trials

The following are studies looking at ways to screen for prostate cancer in people at high risk: 

• NCT05129605: Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS). This study will look at how enhanced prostate cancer screening using MRI will improve early detection rates and further understanding of how inherited mutations can lead to development of prostate cancer.
• NCT03805919: Men at High Genetic Risk for Prostate Cancer. This is a prostate cancer screening study using MRI in high risk men. This study is open to men with an inherited mutation in any of the following genes: BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, MLH1, MSH2, MSH6, PMS2, EPCAM, CHEK2, PALB2, RAD51D, BRIP1 or FANCA.
• NCT04472338: Prostate Screening for Men With Inherited Risk of Developing Aggressive Prostate Cancer, PATROL Study. This study is looking at ways to detect prostate cancer earlier in men who are at increased genetic risk of developing prostate cancer that forms, grows, or spreads quickly (aggressive). The study is open to men with mutations associated with prostate cancer risk. 

• NCT05608694: MRI Screening in Men at High Risk of Developing Prostate Cancer. The purpose of this study is to determine whether or not Magnetic Resonance Images (MRI) will identify high-grade cancers earlier and more frequently in men at high risk of developing prostate cancer.