Genetic testing for inherited mutations may be helpful for all people with advanced or metastatic cancer
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In a study of nearly 12,000 cancer patients with a variety of cancers, eight percent of participants with metastatic cancer had an inherited mutation in a cancer gene that qualified them for a targeted treatment approved by the FDA or for participation in a clinical trial. The majority of people with metastatic cancer were unaware that they had an inherited mutation, and had not receive gene-directed treatment to which their tumor may have responded. The study authors suggest that genetic testing for inherited mutations may be warranted for all patients with advanced or metastatic cancer. (posted 9/30/21)

Expert Guidelines

The National Comprehensive Cancer Network has guidelines on who should undergo genetic counseling and testing. If you have metastatic or advanced cancer, you should speak with a genetics expert about genetic testing if any of the following apply to you:     

This list is not comprehensive; other cancers may also be hereditary. If you are uncertain if you meet the guidelines above and you are interested in or considering undergoing genetic testing, you should speak with a cancer genetics expert

Questions To Ask Your Health Care Provider

Open Clinical Trials

The following studies involve genetic testing in people with advanced cancers:

The following are studies looking at treatment for people with advanced solid tumors. 


FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.