Breast cancer risk for transgender men with inherited mutations
Full article:

There is little information related to the risks and treatment options for transgender men and nonbinary people who are at high-risk for breast cancer due to an inherited BRCA1 or BRCA2 mutation. We review an expert viewpoint on the implications of a BRCA mutation for transgender men undergoing breast removal as part of their gender-affirming care plan. (posted 5/19/22)

Expert Guidelines

Yale NewHaven Health provides management and risk reduction options for transgender men with a BRCA1 or BRCA2 mutation, including the following:


Risk Reduction


The American College of Radiology has guidelines for breast cancer screening of transgender men with varying degrees of risk. For transgender men they recommend the following:

FORCE recommends that you speak with a genetics expert who can review your personal and family history of cancer and help you determine the best risk management and cancer screening plan for you.

Questions To Ask Your Health Care Provider

Open Clinical Trials

The following studies are enrolling people from the LGBTQ+ community. 

Visit our Featured Research Page and Research Search and Enroll Tool to find additional studies enrolling people with, or at high risk for cancer. Note: Most of these trials are geared towards cisgender people.


FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.