More is not better: PARP dose can be safely reduced for people with ovarian cancer

Questions To Ask Your Health Care Provider

• Is olaparib maintenance therapy an option for me?
• What side effects of olaparib therapy could lead to the need to reduce the dose or interrupt treatment?
• How will the side effects of olaparib therapy be monitored and managed?
• How will I know whether I should take my daily olaparib dose or not?

Open Clinical Trials

The following are studies looking at PARP inhibitors and similar agents for treating people with ovarian cancer.  

• NCT03462342 Combination ATR inhibitor and PARP Inhibitor in Recurrent Ovarian Cancer (CAPRI). This study will look at how well patients with recurrent ovarian cancer respond to treatment with a targeted therapy known as an ATR inhibitor when combined with a PARP inhibitor.
• NCT04586335: Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors. The purpose of this study is to assess the safety, tolerability and preliminary efficacy of the targeted therapy CYH33 in combination with olaparib in patients who have DDR gene mutations and/or PIK3CA mutations, have progressed on a prior PARP inhibitor and those with recurrent high grade serous ovarian, fallopian tube or primary peritoneal cancer who are platinum resistant or refractory. 
• NCT03579316: Adavosertib With or Without Olaparib in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer. This studies how well adavosertib with or without olaparib work in patients with ovarian cancer that has come back (recurrent).
• NCT04267939: ATR Inhibitor Plus Niraparib Study in Advanced Solid Tumors and Ovarian Cancer. This study will look at how well people with advanced ovarian cancer or other solid tumors respond to treatment with the targeted therapy BAY1895344 in combination with the PARP inhibitor niraparib. This study is open to people whose ovarian cancer progressed on a PARP inhibitor.