Estrogen without progesterone for hormone replacement may lower breast cancer risk
https://www.facingourrisk.org/XRAY/estrogen-without-progesterone-as-HRT-may-lower-breast-cancer
Full article: https://www.sabcs.org/Portals/SABCS2016/2023%20SABCS/Poster%20Listings/SABCS23%20Poster%20Spotlights%20Block%203.pdf?ver=2023-11-02-162551-740
Women with average breast cancer risk who took estrogen without progesterone after menopause had lower rates of breast cancer than those who did not take any hormone replacement. This finding comes from studies looking at the safety of the use of estrogen alone as hormone replacement therapy. (Posted 2/13/24)
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Questions To Ask Your Health Care Provider
- What are the risks and benefits of taking estrogen?
- If I decide to take hormone replacement, is estrogen alone an option for me?
- What do you recommend to help me feel better as I go through menopause?
- What can I do to decrease my risk of breast cancer?
- Can you refer me to a menopause expert?
Open Clinical Trials
The following are studies on menopause and menopause management for survivors and previvors:
- NCT04439370: Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women. This study will look at the effects of early menopause on blood pressure.
- NCT03572153: A Mind-Body Intervention for Hot Flash Management. The main goal of this study is to test whether self-administered hypnosis can be used to reduce hot flashes more than self-administered white noise hypnosis over 6 weeks of home practice.
- NCT04821141: Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens. Women at increased risk for breast cancer who experience hot flashes will receive bazedoxifene plus conjugated estrogens (similar to the drug Duavee) for 6 months or a control (no drug). Researchers will measure breast density with mammography and needle biopsy that looks at biomarkers.
- NCT06112756: A Study to Learn About How Elinzanetant Works and How Safe it is in Women Having Sleep Disturbances Associated with Menopause (NIRVANA). The study treatment Elinzanetant is being studied to treat symptoms like hot flashes which are caused by hormonal changes associated with menopause. It may block the activity of a protein that has been found to contribute to sleep disturbances.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.