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No one should face hereditary cancer alone.

Thinking about cancer or dealing with cancer risk can be scary or overwhelming, but we believe that receiving information and resources is comforting, empowering, and lifesaving.

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BRCA & HBOC
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Jewish People

Learn more about how HBOC affects members of specific populations.

Special considerations for Jewish people

  • BRCA mutations are found in about 2.5% (one in forty) of Ashkenazi Jewish people.
  • About 40% of Jewish women with ovarian/fallopian tube cancer and 20% who have premenopausal breast cancer have a BRCA mutation.
  • The majority of BRCA mutations in Jewish people occur in one of three sites along the genes, but people of Jewish ancestry can have mutations at other sites along the BRCA1 and BRCA2 genes or in other genes associated with hereditary cancers.
  • BRCA mutations are associated with several types cancers.  Gather your entire family cancer history and speak with a genetics expert about whether the cancers might be hereditary. Cancers related to BRCA mutations include:  
    • Breast
    • Ovarian, fallopian tube, and primary peritoneal 
    • Pancreatic
    • Melanoma 
    • Prostate 
    • Male breast cancer
  • Every woman diagnosed with ovarian cancer meets national guidelines for genetic counseling and testing.  
  • Every man diagnosed with breast cancer meets national guidelines for genetic counseling and testing.
  • Anyone with Ashkenazi Jewish ancestry diagnosed with breast, pancreatic, or ovarian cancer at any age meets national guidelines for genetic counseling and testing.  
  • People who test positive for a BRCA mutation have options to lower the risk for cancer or detect it at an earlier, more treatable stage.
  • Fanconi Anemia is a rare inherited disorder that can affect children who inherit two BRCA2 gene mutations, one from each parent. If both parents have a BRCA2 mutation, their children are at risk for this disease. This is more likely when both of the parents are of Jewish descent.

Updated 12/30/16

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