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Testing Immunotherapy Treatments for Recurrent Endometrial Cancer

Clinicaltrials.gov identifier:
NCT05112601

Treatment
Treatment study for people with endometrial cancer that has returned

Study Contact Information:

For additional information, please contact: the Principal Investigator: Haider S Mahdi at NRG Oncology 412-641-5609 or [email protected]

Testing Immunotherapy Treatments for Recurrent Endometrial Cancer

About the Study

This study tests the combination of two drugs compared to one drug to shrink tumors in patients with endometrial cancer that has returned after not being detected for a period of time (recurrent). The study is enrolling people with a known as .

What the Study Involves

This study involves 2 groups:

  • Group 1:
    Patients will receive both nivolumab and ipilimumab injected into the vein on day 1 of every other cycle. Cycles will repeat every three weeks and will be repeated for up to eight cycles.
  • Group 2:
    Patients will receive nivolumab injected into the vein on day 1 of each cycle. This will repeat every three weeks for every eight weeks.

Study Sites

Georgia

Augusta
Augusta University Medical Center
Contact: Site Public Contact 706-721-2388 [email protected]

Iowa

Iowa City
University of Iowa/Holden Comprehensive Cancer Center
Contact: Site Public Contact 800-237-1225

Missouri

Saint Louis
Washington University School of Medicine
Contact: Site Public Contact 800-600-3606 [email protected]

New Mexico

Albuquerque
University of New Mexico Cancer Center
Contact: Site Public Contact 505-925-0348 [email protected]

Ohio

Cleveland
Case Western Reserve University
Contact: Site Public Contact 800-641-2422 [email protected]

Cleveland
Cleveland Clinic Foundation
Contact: Site Public Contact 866-223-8100 [email protected]

Oklahoma

Oklahoma City
University of Oklahoma Health Sciences Center
Contact: Site Public Contact 405-271-8777 [email protected]

Pennsylvania

Philadelphia
NRG Oncology
Contact: Haider S. Mahdi 412-641-5609 [email protected]

Pittsburgh
University of Pittsburgh Cancer Institute (UPCI)
Contact: Site Public Contact 412-647-8073

Rhode Island

Providence
Women and Infants Hospital
Contact: Site Public Contact 401-274-1122

Virginia

Charlottesville
University of Virginia Cancer Center
Contact: Site Public Contact 434-243-6303 [email protected]

Washington

Seattle
Fred Hutchinson Cancer Research Center
Contact: Site Public Contact 800-804-8824

This Study is Open To:

People 18 years or older who:

  • have detectable recurrent endometrial cancer with (deficient mismatch repair)
  • have received 1-2 prior lines of treatment, but must have been stopped at least 4 weeks prior to the start of the trial
  • have recovered from the effects of any recent surgeries or cancer treatments
  • agree to use contraceptives prior to the study and five months following following the study, as well as test negative for pregnancy or not be breastfeeding
  • do not have detectable HBV, HIV or HCV
This Study is Not Open To:

People who:

  • have a diagnosis of endometrial serous cancer
  • are receiving immunosuppressive therapy
  • have an active autoimmune disease or weak immune systems that may be unable to respond to the treatment
  • are pregnant or unwilling to stop nursing
  • have had prior therapy with a treatment similar to the therapy being used in the trial
  • have had a history of allergic reactions to materials similar to the treatment being given in the study