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Hereditary Cancer Info > Risk Management > Risk Management Guidelines

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Risk Management Guidelines

Learn about the steps that people at high risk for cancer can take to manage their risk and protect their health.

Guidelines for men and women with Peutz-Jeghers syndrome (STK11 mutations)

Breast and ovarian cancer screening for women

  • Clinical breast exam every 6 months beginning at age 25
  • Annual breast MRI and mammogram beginning at age 25
  • Annual pelvic exam and PAP smear beginning at age 18-20
  • Consider transvaginal ultrasound beginning at age 18-20

Cancer screnning for men 

  • Annual testicular exam 

Guidelines for men and women 

  • Colonoscopy every 2-3 years beginning in late teens
  • Upper endoscopy every 2-3 years beginning in late teens
  • Small bowel CT, MRI or video capsule endoscopy starting at age 8-10 with a followup by age 18, and then every 2-3 years
  • Magnetic resonance cholangiopancreatography with contrast or endoscopic ultrasound every 1-2 years beginning age 30-35

Reproductive options

  • For patients of reproductive age, advise about options for prenatal diagnosis and assisted reproduction including pre-implantation genetic diagnosis. 

Risk to relatives

  • Advise about possible inherited cancer risk to relatives, options for risk assessment, and management. 
  • Recommend genetic counseling and consideration of genetic testing for at-risk relatives. 


Updated 11/05/2018

FORCE:Facing Our Risk of Cancer Empowered