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Breast Cancer Chemoprevention

Learn about the steps that people at high risk for cancer can take to manage their risk and protect their health.

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Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial
Jack Cuzick, PhD, Ivana Sestak, PhD, Simon Cawthorn, MD, Hisham Hamed, MD, Prof Kaija Holli, MD, Prof Anthony Howell, MD, Prof John F Forbes, MD, on behalf of the IBIS-I Investigators. The Lancet Oncology. Volume 16, No. 1, p67–75, January 2015.

Update on long-term followup from IBIS study after 16 years of follow up showed that Tamoxifen continued to protect high risk women from hormone sensitive cancers even after stopping the medication.

Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoifen and Raloxifene (STAR) P-2 Trial: Preventing Breast Cancer
Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, Bevers TB, Fehrenbacher L, Pajon ER, Wade JL 3rd, Robidoux A, Margolese RG, James J, Runowicz CD, Ganz PA, Reis SE, McCaskill-Stevens W, Ford LG, Jordan VC, Wolmark N; National Surgical Adjuvant Breast and Bowel Project.

Raloxifene and tamoxifen lower the risk for breast cancer in high-risk women. Tamoxifen is slightly better at preventing invasive breast cancer but raloxifene had less toxicity than tamoxifen.

Long-term follow-up in cancer prevention trials (it ain't over 'til it's over)
Cuzick J, Cancer Prevention Research, Vol. 3, No. 6, pp. 689-91 (2010).

Author provides insights about long term follow-up breast cancer chemoprevention studies.

Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer
U. Veronesi, L. Mariani, A. Decensi, F. Formelli, T. Camerini, R. Miceli, M. G. Di Mauro, A. Costa, E. Marubini, M. B. Sporn and G. De Palo. Annals of Oncology. Volume 17, Number 7: p. 1065-1071, July, 2006.

Statins reduce breast cancer risk: a case control study in US female veterans
R. Kochhar, V. Khurana, H. Bejjanki, G. Caldito, C. Fort American Society of Clinical Oncologists. (abstract # 514), May 2005. (Annual conference proceedings abstract)

Factor V Leiden (FVL) mutations and thromboembolic events (TE) in women with breast cancer on adjuvant tamoxifen
J. E. Garber, S. Halabi, E. Kaplan, S. Edge, L. Dressler, E. Paskett, N. Berliner, Cancer and Leukemia Group. American Society of Clinical Oncologists. (abstract # 508), May 2005. (Annual conference proceedings abstract)

Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention
SD Solomon, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, Anderson WF, Zauber A, Hawk E, Bertagnolli M; Adenoma Prevention with Celecoxib (APC) Study Investigators. New England Journal of Medicine. Volume 17, Number 11: p. 1071-80, March 2005

Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer
Anthony Howell, Cuzick J, Baum M, Buzdar A, Dowsett M, Forbes JF, Hoctin-Boes G, Houghton J, Locker GY, Tobias JS; ATAC Trialists' Group. Lancet. Volume 365, Number 9453: p. 60-62, January 2005.

Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs
Randall E. Harris, Rowan T. Chlebowski, Rebecca D. Jackson, David J. Frid, Joao L. Ascenseo, Garnet Anderson, Aimee Loar, Rebecca J. Rodabough, Emily White and Anne McTiernan. Cancer Research. Volume: 63, Issue 18: p. 6096-6101, September 15, 2003

A gonadotropin-releasing hormone agonist (GnRHA)-based chemoprevention regimen that reduces mammographic density in BRCA carriers while maintaining good quality of life (QOL), bone density and reproductive options
J. Weitzel, S. Buys, M. C. Pike, A. Daniels, G. Ursin, J. R. Daniels, D. J. MacDonald, K. R. Blazer, D. V. Spicer. American Society of Clinical Oncologists. Volume 22: p. 94, (abstract # 374), June 2003. (Annual conference proceedings abstract)

Effects of Tamoxifen on Benign Breast Disease in Women at High Risk for Breast Cancer
Elizabeth Tan-Chiu, Jiping Wang, Joseph P. Costantino, Soonmyung Paik, Cheryl Butch, D. Lawrence Wickerham, Bernard Fisher, Norman Wolmark. Journal of the National Cancer Institute. Volume 95, Number 4: p. 302-307, February 2003. (Full text)

Oral Contraceptives and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers
Steven A. Narod, Marie-Pierre Dubé, Jan Klijn, Jan Lubinski, Henry T. Lynch, Parviz Ghadirian, Diane Provencher, Ketil Heimdal, Pal Moller, Mark Robson, Kenneth Offit, Claudine Isaacs, Barbara Weber, Eitan Friedman, Ruth Gershoni-Baruch, Gad Rennert, Barbara Pasini, Theresa Wagner, Mary Daly, Judy E. Garber, Susan L. Neuhausen, Peter Ainsworth, Hakan Olsson, Gareth Evans, Michael Osborne, Fergus Couch, William D. Foulkes, Ellen Warner, Charmaine Kim-Sing, Olufunmilayo Olopade, Nadine Tung, Howard M. Saal, Jeffrey Weitzel, Sofia Merajver, Marion Gauthier-Villars, Helena Jernstrom, Ping Sun, Jean-Sebastien Brunet. Journal of the National Cancer Institute. Volume 94, Number 23: p. 1773-1779, December 2002.

Tamoxifen and Breast Cancer Incidence Among Women With Inherited Mutations in BRCA1 and BRCA2
Mary-Claire King, PhD; Sam Wieand, PhD; Kathryn Hale, BS; Ming Lee, PhD; Tom Walsh, PhD; Kelly Owens, PhD; Jonathan Tait, MD, PhD; Leslie Ford, MD; Barbara K. Dunn, MD, PhD; Joseph Costantino, DrPH; Lawrence Wickerham, MD; Norman Wolmark, MD; Bernard Fisher, MD. Journal of the American Medical Association. Volume 286: p. 2251-2256, November 2001.

Tamoxifen and risk of contralateral breast cancer in and mutation carriers: a case-control study
Narod SA, Brunet JS, Ghadirian P, Robson M, Heimdal K, Neuhausen SL, Stoppa-Lyonnet D, Lerman C, Pasini B, de los Rios P, Weber B, Lynch H, Hereditary Breast Cancer Clinical Study Group. Lancet. Volume 356, Issue 9245: p. 1876-81, December 2000.

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
Bernard Fisher, Joseph P. Costantino, D. Lawrence Wickerham, Carol K. Redmond, Maureen Kavanah, Walter M. Cronin, Victor Vogel, André Robidoux, Nikolay Dimitrov, James Atkins, Mary Daly, Samuel Wieand, Elizabeth Tan-Chiu, Leslie Ford, Norman Wolmark, and other National Surgical Adjuvant Breast and Bowel Project Investigators. Journal of the National Cancer Institute. Volume 90, Number 18: p. 1371-1388, September 1998.

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