TP53 Inherited Mutations (Li-Fraumeni Syndrome)
Learn about the cancer risks and medical options for people with inherited TP53 mutationsStay up to date on research and information
Sign Up for FORCE NewslettersInformation for People with Inherited Mutations
mutations cause a condition known as . People with an in have a very high lifetime risk for different types of cancers, including:
- brain cancer
- breast cancer
- colorectal cancer
- pancreatic cancer
- sarcomas
- other cancers
The risks for cancer begin at a very young age.
There are expert guidelines with recommendations for screening and prevention of these cancers.
There may be family planning considerations and options for people with an inherited mutation.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
People with a mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Other Considerations
People with mutations can develop cancer beginning at an early age. Learn about other important considerations for people with inherited mutations.
More Resources
Participate in Research
The studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier:
NCT05129605
Observing People and Families Affected by Li-Fraumeni Syndrome (TP53 Mutation )
Clinicaltrials.gov identifier:
NCT01443468