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Hereditary Cancer & Genetics

Learn about genes and cancer, signs of hereditary cancer, genetic counseling, types of genetic tests and what results mean for you and your family.

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Hereditary breast and ovarian cancer and other hereditary syndromes: using technology to identify carriers
Brian Drohan, PhD, Constance A. Roche, MSN, RN, James C. Cusack Jr., MD, and Kevin S. Hughes, MD. Ann Surg Oncol. Volume. 19:6. p. 1732–1737, June 2012.

Provides estimates on the number of people in the US with a BRCAmutation and how many people have been tested.

Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing
Walsh, T., Casadei, S., Ming, L., Pennil, C., Nord, A., Thornton, A., Roeb, W. Agnew, K., Stray, S., Wickramanayake, A., Norquist, B., Pennington, K., Garcia, R., King, MC and Swisher, E. Proceedings of the National Academy of Sciences. Vol. 108: no. 44 p. 18032-18037. November 2011.

Referral for cancer genetics consultation: a review and compilation of risk assessment criteria
Heather Hampel, K Sweet, J A Westman1, K Offit and C Eng. Journal of Medical Genetics. Volume 41, Issue 2: p. 81-91, February 2004.

TGFBR1*6A and cancer risk: A meta-analysis of seven case-control studies
Virginia G. Kaklamani, Nanjiang Hou, Yiansong Bian, Jennifer Reich, Kenneth Offit, Loren S. Michel, W.S. Rubinstein, Alfred Rademaker, Boris Pasche. Journal of Clinical Oncology. Volume 21, Issue 17: p. 3236-3243, September 2003.

Frequency of CHEK2*1100delC in New York breast cancer cases and controls
Kenneth Offit, Heather Pierce, Tomas Kirchhoff, Prema Kolachana, Beth Rapaport, Peter Gregersen, Steven Johnson, Orit Yossepowitch, Helen Huang, Jaya Satagopan, Mark Robson, Lauren Scheuer, Khedoudja Nafa, Nathan Ellis. BMC Medical Genetics. Volume 4, Issue 1: p.1, January 2003

Breast cancer genetics in African Americans
Olufunmilayo I. Olopade, M.B., B.S., James D. Fackenthal, Ph.D., Georgia Dunston, Ph.D., Michael A. Tainsky, MD, Ph.D., Francis Collins, M.D., Ph.D., Carolyn Whitfield-Broome, Ph.D. Cancer. Volume 97, Issue S1: p. 236-245, December 2002.

Understanding Hereditary Cancer in the Era of Multi-Gene Panel Testing: Collaborative Best Practices Review and Recommendations January 2016
A white paper from 14 advocacy groups discussing best practices for panel testing.

FORCE:Facing Our Risk of Cancer Empowered