Thinking about cancer or dealing with cancer risk can be scary or overwhelming, but we believe that receiving information and resources is comforting, empowering, and lifesaving.
Patient-Driven Clinical Classification of Genetic VUS (Variants of Uncertain Significance)
Find My Variant is a research study designed to help individuals and families understand more about their variants, educate and help individuals and families find more information about the VUSs that are unique to them, and help individuals identify and collect DNA samples from their family members in order to learn more about their VUS.
Headline Hype: Media Report on BRCA1 Variant Research Plays on Fears
A media report hypes new genetic research to classify "variants of uncertain significance" and plays on the fears people may have about the accuracy of genetic test results.
PALB2 and Breast Cancer Risk
2014 research review article on the risk of breast cancer for women with PALB2 mutations.
New Tools Help with Uncertain or Negative BRCA Results
Article in Spring 2014 Joining FORCEs Newsletter about advances in genetic testing which can find more mutations that lead to cancer in families.
Using Multiple-Gene Panels for Medical Decisions
Article in Spring 2014 Joining FORCEs Newsletter about new genetic tests for multiple genes.
BROCA Test for Ovarian Cancer Risk
Article in Fall 2012 Joining FORCEs Newsletter about new test for ovarian cancer risk in BRCA-negative families.
Are Women Who Test True Negative for BRCA at Increased Risk of Cancer
Article in Spring 2014 Joining FORCEs Newsletter reviews the research on risk for cancer in women who test negative for a family BRCA mutation.
Genetic Mutation Database
Our genetic mutation database can help people search for a particular mutation and connect with others who have the same mutation. Use the Mutation Search Form to search by mutation, or ethnicity.
Noncarriers in BRCA1/BRCA2 families do not have increased risk of breast cancer
Article on research from 2011 indicating that women who test "true negative" (they didn't inherit the BRCA mutation in their family) do not have elevated risk for breast cancer.
Genetics 101 Webinar
Is the cancer in your family hereditary? Dr. Sutphen reviews the different types of hereditary syndromes and mutations that can lead to cancer within a family; the types of genetic tests available for these syndromes; cancer risks associated with different hereditary syndromes; why hereditary cancers are different from sporadic cancers, and how hereditary cancers develop.
BRCA Testing: When Negative Results May Still Mean High Risk
Fall 2006 FORCE newsletter article on inconclusive negative BRCA test results
Spring 2007 FORCE newsletter article on controversial hypothesis that women who test “true negative” for a BRCA mutation may still be at higher risk than average for breast cancer
Prevalence of BRCA Mutations Underestimated in Asian American Women
Winter 2009 article with personal account and results from research on prevalence of BRCA in Asian women
Surviving Breast Cancer: African-American Women and the Importance of Genetic Testing
Fall 2005 FORCE newsletter article about genetic counseling and testing for African-American women
Testing BRCA Negative: Could it be Cowden Syndrome?
Spring 2008 FORCE newsletter article on Cowden Syndrome, a hereditary cancer syndrome with increased risk for breast cancer.
Genetic Testing Research for BRCA-Negative Families with Ovarian Cancer
Article in Fall 2012 Joining FORCEs Newsletter about research for families with ovarian cancer but no known mutation.
by Joi Morris and Ora Gordon, MD
One part memoir, three parts guidebook, Positive Results explains in a clear and steady manner the myths and realities of “the breast cancer genes.”
A global resource that includes data on thousands of inherited variants in the BRCA1 and BRCA2 genes is available to the public.
Quest Diagnostics BRCAvantage
Quest Diagnostics offers several options for BRCA testing including single-site analysis, Ashkenazi Founder mutation panels and rearrangement testing. Speak with a genetic counselor to assure that the most appropriate tests are ordered and properly interpreted.
Ambry Genetics offers multiple genetic panels that include BRCA 1 and BRCA 2 gene tests. Speak with a genetic counselor to assure that the most appropriate tests are ordered and properly interpreted. Ambry has stated that they will be submitting variant results into ClinVar.
University of Washington Genetics Lab
Offers gene panel testing and single site testing for specific gene mutations. Speak with a genetic counselor to assure that the most appropriate tests are ordered and properly interpreted.
Ethigen offers BRCA 1 and BRCA 2 testing as well as testing for other hereditary syndromes. They emphasize the importance of genetic counseling and work with experts to assure the most appropriate tests are ordered and properly interpreted. Their website states that they support the campaign for the open sharing of classifying variants.
Website says they are offering BRCA testing. Speak with a genetic counselor to assure that the most appropriate tests are ordered and properly interpreted.
InVitae offers a variety of hereditary cancer testing panels. Speak with a genetic counselor to assure that the most appropriate tests are ordered and properly interpreted.
Information for consumers and health care providers, including charts of BRCA prevalence, produced by the laboratory that conducts BRCA 1 and BRCA 2 testing
Genetic Testing for Breast and Ovarian Cancer Risk
A good introduction from the National Cancer Institute.
In the Family
This documentary film follows the story of previvor Joanna Rudnick and several families affected by hereditary breast and ovarian cancer.
Understanding your negative BRCA test result
This website is maintained by the Ferre Institute, Inc., a non-profit organization that provides services in genetics and reproductive health.
ACLU Challenges Patents On Breast Cancer Genes: BRCA
Website for the American Civil Liberties Union, with information about their lawsuit against Myriad Genetics over their patent of the BRCA genes.
Ferre Institute has created a resource for individuals who have undergone testing for two of the genes that cause the majority of hereditary breast and ovarian cancer, BRCA1 and BRCA2, and have tested negative or have been found to have a variant.