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Prostate Cancer Treatment

There are many options for treating hereditary cancers. Choice of treatment can be personalized based on cancer type, stage and genetics.

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Inherited DNA-repair Gene Mutations in Men with Metastatic Prostate Cancer
Pritchard C, Mateo J, Walsh M, De Sarkar N, Nelson P, New England Journal of Medicine 2016; 375(5):443-53.

Biallelic Inactivation of BRCA2 in Platinum-sensitive Metastatic Castration-resistant Prostate Cancer
Cheng H, Pritchard C, Boyd T, Nelson P, and Montgomery B. European Urology 2016; 69(6): 992-95.

DNA-repair Defects and Olaparib in Metastatic Prostate Cancer
Mateo J, Carreira S, Sandhu S, Miranda S, et. al. New England Journal of Medicine 2015; 373(18):1697-1708.

Effect of BRCA mutations on metastatic relapse and cause-specific survival after radical treatment for localised prostate cancer
Castro E, Goh C, Leongamornlert D, Saunders E, Eeles R et. al. Eur Urol 2015; 68:186–93.

Clinical Management of Prostate Cancer in Men with BRCA Mutations.”
Bratt O and Loman N. Eur Urol 2015; 68:194–95.

Clinical features and management of BRCA1 and BRCA2-associated prostate cancer
Alanee S, Glogowski E, Schrader K, Eastham J, and Offit K. Frontiers in Bioscience 2014; 6:15-30.

Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer
Castro E, Goh C, Olmos D, Saunders E, Eeles R et. al. J Clin Oncol 2013; 31:1748–57.

Genetic susceptibility to aggressive prostate cancer.
Ostrander E, Kwon E and Stanford J. Cancer Epidemiol Biomarkers Prev 2006; 15(10):1761-64.

Prostate cancer progression and survival in BRCA2 mutation carriers
Tryggvadottir L, Vidarsdottir L, Thorgeirsson T, et. al. J Natl Cancer Inst 2007; 99(12):929-35.

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