Men at High Genetic Risk for Prostate Cancer

Research Cycle:
Conduct Research

Lead Researcher:
William L Dahut, MD, National Cancer Institute (NCI)

Type of Research:
Cancer Screening and Prevention

Men at High Genetic Risk for Prostate Cancer

Study background

Men with an inherited mutation linked to increased risk for prostate cancer may benefit from enhanced cancer screening. Current standard screening includes digital rectal exams and PSA blood tests. These tests are not always reliable, and scientists are looking for better ways to detect prostate cancer. 

Study goals

The National Cancer Institute opened a clinical trial for prostate cancer screening study looking at a new type of MRI to improve prostate cancer detection. The goals of the study are to test the feasibility and accuracy of multi-parametric magnetic resonance imaging (mpMRI) for:

  • the localization and detection of local prostate cancer
  • to monitoring participants on active surveillance
  • as a follow up tool for monitoring local disease progression


FORCE and ABOUT Network role

FORCE raises awareness about the importance of men knowing their risk for cancer. We encourage high-risk men to be proactive with cancer screening and prevention. FORCE is actively promoted enrollment into this research study. You can learn more about the study and how to enroll on our Featured Research page

“Thank you for promoting our prostate cancer screening study on your website. The turnout has been great with over 38% of all referrals coming from FORCE!!!” - Anna Couvillon, CRNP, Researcher, National Cancer Institute

This research is relevant for:

People who test positive for an inherited mutation

People with a family history of cancer

People at high risk for prostate cancer