CTNNA1 Familial Expansion Study (CAFÉ)
https://www.facingourrisk.org/research-clinical-trials/study/441 /ctnna1-familial-expansion-study-cafe
Clinicaltrials.gov identifier:
NCT05126290 (https://clinicaltrials.gov/show/NCT05126290)
Surveys, Registries, Interviews
Observational study enrolling adults who carry a CTNNA1 loss-of-function variant or are first-degree relatives of a carrier
Study Contact Information:
Study Contact: Bryson Katona, MD, PhD
Phone: 215-349-8222
Email: [email protected]
About the Study
The CTNNA1 Familial Expansion (CAFÉ) Study is an observational study that aims to better understand cancer risks associated with changes in the CTNNA1 gene. Researchers are studying loss-of-function variants, which are genetic changes that can prevent a gene from functioning normally.
Researchers will collect personal medical, genetic, and family health history from people who carry a CTNNA1 loss-of-function variant and their first-degree relatives. The study aims to determine whether certain CTNNA1 variants are associated with specific types of cancer, including stomach (gastric) cancer and breast cancer.
The findings may help researchers better understand cancer risks associated with CTNNA1 variants and inform future approaches to managing cancer risk in affected families.
What the Study Involves
Participants will provide information about their personal medical history, genetic test results, and family health history through an online data entry system. The research team may contact participants in the future to obtain additional information about their health or their family's health.
Participation is expected to average one year.
This Study is Open To:
- Adults aged 18 or older who carry a CTNNA1 loss-of-function variant.
- Adults aged 18 or older who are a first-degree relative (parent, sibling, or child) of someone who carries a CTNNA1 loss-of-function variant.
This Study is Not Open To:
- People younger than 18 years old.
- People who do not carry a CTNNA1 loss-of-function variant and are not a first-degree relative of a carrier.
- People who cannot speak and read English.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.