MRI Screening in Men at High Risk of Developing Prostate Cancer

https://www.facingourrisk.org/research-clinical-trials/study/260/screening-in-men-at-high-risk-of-developing-prostate-cancer

Clinicaltrials.gov identifier:
NCT05608694 (https://clinicaltrials.gov/show/NCT05608694)

Prevention
Screening using MRI for men at risk of developing prostate cancer

Study Contact Information:

Please contact Contact: Scott Eggener, MD (773) 702-1001 [email protected] or
Mitchell Oddo (773) 834-8771 [email protected]

About the Study

This study will place participants into one of four groups:

Group 1: Men with inherited mutations in the following genes: ATM, BRCA1, BRCA2, CHEK2, EPCAM, HOXB13, MLH1, MSH2, MSH6, PALB2 and PMS2
Group 2: Men who have a high risk of prostate cancer based on their genetic risk score (GRS)
Group 3: Men with a family history of prostate cancer in at least one sibling, father, uncle, or grandfather
Group 4: Men at low risk of prostate cancer

All groups will receive the same prostate MRIs.

What the Study Involves

Participants will have a prostate MRI every three years for 15 years or until prostate cancer is found.

This Study is Open To:

Men 18 years and older who:

Have not had prostate cancer
Have not had prostate surgery

This Study is Not Open To:

Men who do not meet the inclusion criteria defined above and those who:

Cannot have an MRI
Do not have a rectum
Have had a hip replacement
Have had a prostate biopsy or MRI within the last three years

About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.