Blood Markers of Early Pancreas Cancer
Screening for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk.
Study Contact Information:
For additional information, please contact: Christina L Hoy, DNP by phone: 402-559-1577 or by email, or
Kelsey A Klute, MD by phone: 402-559-8500 or by email
About the Study
The purpose of this study is to try to find markers of early pancreatic cancer for screening for individuals at higher-than-average risk, expedite the diagnosis in individuals with symptoms, and substantially improve an individual's chance of surviving the disease.
What the Study Entails
Each study participant will undergo blood tests that measure a blood sugar marker called Hemoglobin A1c as well as other markers.
Participants may include people at high risk for pancreatic cancer due to the following:
- people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk, including the following: BRCA1, BRCA2, PALB2, APC, CKDN2a, p16, STK11, ATM, SMAD4, BMPR1A, TP53, CFTR or Lynch syndrome (EPCAM, MLH1, MSH2, MSH6, PMS2).
- people with cystic pancreas lesions or chronic pancreatitis.
- people with new-onset diabetes.
Study participants will be followed for five years.
- Omaha, Nebraska
Nebraska Medical Center
Contact: Christina Hoy, DNP by phone: 402-559-1577 or by email
This Study is Open To:
Men and women age 19 years or older can be considered for enrollment in this study if they meet one of the following criteria:
- Have new onset type 2 diabetes, or are considered high-risk pre-diabetes
- Have pancreatic neoplasms (abnormal growths) or pancreatitis
- Have family history of pancreatic cancer or have an increased risk due to an inherited mutation in any one of the following genes: BRCA1, BRCA2, PALB2, EPCAM, MLH1, MSH2, MSH6, PMS2, APC, CKDN2a, p16, STK11, ATM, SMAD4, BMPR1A, TP53, CFTR
This Study is Not Open To:
- Patients with a personal history of pancreatic cancer
- Patients who are currently receiving treatment for a cancer diagnosis (excluding long-term hormonal therapy)
- Patients who are pre-diabetic and taking metformin for 3 or more years
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.