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Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. You can do a quick search to filter our featured studies by cancer type, study type or key word, or a more in-depth search through clinicaltrials.gov.

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Search Results: Prevention, Detection & Risk (10 results)

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Men at High Genetic Risk for Prostate Cancer

Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation

Men at High Genetic Risk for Prostate Cancer

The National Institutes of Health has a clinical trial for men at high genetic risk for prostate cancer. This is trial is for men without prostate cancer, ages 30 to 75, who have tested positive for Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or FANC (FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, and FANCM). The trial involves screening MRI of the prostate every two years and biopsy of the prostate if the MRI is abnormal. There is no cost for travel or study-related tests. 

Clinicaltrials.gov identifier: NCT03805919
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Cancer Prevention Vaccine (Nous-209) for People with Lynch Syndrome

Prevention
Prevention study for people with Lynch syndrome

Cancer Prevention Vaccine (Nous-209) for People with Lynch Syndrome

This study is testing a vaccine, known as the Nous-209 vaccine, which is intended to decrease the chances that people with Lynch syndrome will develop polyps that can turn into cancer.

Clinicaltrials.gov identifier: NCT05078866
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Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome

Prevention
Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome

Lynch Syndrome Vaccine Study

This study is being done to assess the safety and effectiveness of a series of vaccines (Tri-Ad5), together with another drug (N-803) that magnifies the body’s response to vaccines, to see if there is an effect on the risk of developing colon and other cancers in LS patients.

Clinicaltrials.gov identifier: NCT05419011
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Early Detection of Colorectal Cancer for People with Lynch Syndrome

Prevention
People with Lynch Syndrome at risk for colon cancer

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Precancerous Polyps in Lynch Syndrome Patients, CORAL Study

This study will colect blood and stool samples to detect colorectal cancer or precancerous polyps in people with Lynch syndrome.

Clinicaltrials.gov identifier: NCT05410977
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Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome

Prevention
Prevention study for people with Lynch syndrome

A Study Comparing Two Anti-inflammatory Medications Naproxen or Aspirin for Cancer Prevention in Lynch Syndrome

The trial is enrolling people with Lynch syndrome. On average, the length of this study will last one year from the start of enrollment to completion. The study will measure  the effect of naproxen or aspirin on the immune cells in the gastrointestinal tract of people with Lynch syndrome. The trial will also evaluate any symptoms from the medications and any other changes of the colon and rectum.

Clinicaltrials.gov identifier: NCT05411718
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Blood Markers of Early Pancreas Cancer

Prevention
Observational study for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk.

Blood Markers of Early Pancreas Cancer

The purpose of this study is to try to find markers of early pancreatic cancer for individuals at higher-than-average risk, expedite the diagnosis in individuals with symptoms, and substantially improve an individual's chance of surviving the disease.

Clinicaltrials.gov identifier: NCT03568630
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Helping People With a Genetic Mutation in BRCA1, BRCA2 or Lynch Syndrome Talk to Their Family Members About Their Risk for Cancer and Find the Best Way to Get Family Members Tested

Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested

IGNITE-TX - Identifying Individuals for Genetic Testing for Familial Cancer

The IGNITE-TX study is all about helping people with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome talk to their family members about their risk for cancer and find the best way to get family members tested.

Clinicaltrials.gov identifier: NCT05677048
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Atorvastatin ± Aspirin for Colorectal Cancer Prevention for People with Lynch Syndrome

Prevention

Atorvastatin ± Aspirin for Colorectal Cancer Prevention for People with Lynch Syndrome

This study will look at how well atorvastatin (a cholesterol lowering agent) works with or without aspirin in preventing colorectal cancer in people with Lynch syndrome. Atorvastatin may lower the risk of developing cancers in the colon and rectum. Aspirin may reduce the risk of colon polyps and colon cancers. Giving atorvastatin and aspirin may work better at reducing the risk of colorectal cancer (CRC) in high-risk individuals with Lynch syndrome.

Clinicaltrials.gov identifier: NCT04379999
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Pancreatic Cancer Screening Study for High Risk People

Prevention

A Pancreatic Cancer Screening Study for High Risk Individuals

The purpose of this study is to screen and detect pancreatic cancer and precancer in people with either a strong family history of pancreatic cancer, or an inherited mutation associated with pancreatic cancer risk.

Magnetic Resonance Imaging (MRI) will be used to screen for early stage pancreatic cancer. Participants will also be asked to donate a blood sample at specific intervals for the creation of a blood bank necessary for the development of a blood-based screening test for pancreatic cancer. 

Clinicaltrials.gov identifier: NCT03250078
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Pancreatic Cancer Early Detection

Prevention

Pancreatic Cancer Early Detection Program

This is a study looking at esophageal ultrasound and Magnetic Resonance Imaging (MRI) as a screening for pancreatic cancer in high risk individuals. 

Clinicaltrials.gov identifier: NCT02206360
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Additional Results on Clinicaltrials.gov Prevention, Detection & Risk + lynch syndrome
4 results
Clinical Trial Official Title
NCT05129605 Prostate Cancer Genetic Risk Evaluation and Screening Study
NCT05410977 Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients, CORAL Study
NCT03568630 Blood Markers of Early Pancreas Cancer
NCT02206360 Pancreatic Cancer Early Detection Program

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