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Search Results: Prevention, Detection & Risk + Colorectal Cancer (7 results)

Lynch Syndrome Vaccine Study

https://www.facingourrisk.org/research-clinical-trials/study/273/testing-a-combination-of-vaccines-for-cancer-prevention-in-lynch-syndrome

Prevention
Testing a combination of vaccines for cancer prevention in Lynch syndrome

This study is being done to assess the safety and effectiveness of a series of vaccines (Tri-Ad5), together with another drug (N-803) that magnifies the body’s response to vaccines, to see if there is an effect on the risk of developing colon and other cancers in LS patients.


Testing the Safety And Action of the Investigational Drug REC-4881 in People With Familial Adenomatous Polyposis (FAP) (TUPELO Study)

https://www.facingourrisk.org/research-clinical-trials/study/288/testing-the-safety-and-action-of-the-investigational-drug-rec-4881-in-people-with-familial-adenomatous-polyposis-fap

Prevention
Prevention study for people with an APC mutation and FAP who have had colectomy surgery

This study is looking at how safe and effective the research drug REC-4881 is for treating polyps in people with Familial Adenomatous Polyposis (FAP). Participants will receive the oral drug REC-4881. A participant's dose will depend on when they join the study. 


Collecting Blood and Stool Samples to Detect Colorectal Cancer or Precancerous Polyps in Lynch Syndrome Patients, CORAL Study

https://www.facingourrisk.org/research-clinical-trials/study/256/early-detection-of-colorectal-cancer-for-people-with-lynch-syndrome

Prevention
People with Lynch Syndrome at risk for colon cancer

This study will colect blood and stool samples to detect colorectal cancer or precancerous polyps in people with Lynch syndrome and those diagnosed with early onset colorectal cancer, diagnosed younger than 50 years old. 


My Best GI Eating Study

https://www.facingourrisk.org/research-clinical-trials/study/258/my-best-gi-eating-study

Prevention
Diet and weight loss study for people who are overweight and at increased risk of colorectal cancer

This study will test three different diets in people who are overweight and who have an increased risk of colorectal cancer. The study will look at whether these diets improve eating and possibly lead to weight loss. 

 


Testing the Drug Obeticholic Acid for Familial Adenomatous Polyposis

https://www.facingourrisk.org/research-clinical-trials/study/289/testing-the-drug-obeticholic-acid-for-familial-adenomatous-polyposis

Prevention
Prevention study for people with an APC mutation and FAP or AFAP who have polyps in remaining tissue after colectomy surgery

This study is looking at whether obeticholic acid (OCA) is safe and has a beneficial effect on the number of polyps in the small bowel and colon in people with familial adenomatous polyposis (FAP). OCA is a drug similar to a bile acid the body's liver makes. Researchers believe OCA may help keeping cancer from developing. OCA is already FDA approved to treat a type of liver disease. There have been studies showing that OCA decreases inflammation and fibrosis. However, it is not yet known whether OCA works on reducing the number of polyps in patients with FAP.


A Study Comparing Two Anti-inflammatory Medications Naproxen or Aspirin for Cancer Prevention in Lynch Syndrome

https://www.facingourrisk.org/research-clinical-trials/study/281/studying-the-use-of-naproxen-and-aspirin-for-cancer-prevention-in-people-with-lynch-syndrome

Prevention
Prevention study for people with Lynch syndrome

The trial is enrolling people with Lynch syndrome. On average, the length of this study will last one year from the start of enrollment to completion. The study will measure  the effect of naproxen or aspirin on the immune cells in the gastrointestinal tract of people with Lynch syndrome. The trial will also evaluate any symptoms from the medications and any other changes of the colon and rectum.


IGNITE-TX - Identifying Individuals for Genetic Testing for Familial Cancer

https://www.facingourrisk.org/research-clinical-trials/study/266/helping-people-with-a-genetic-mutation-in-brca1-brca2-or-lynch-syndrome-talk-to-their-family-members-about-their-risk-for-cancer-and-find-the-best-way-to-get-family-members-tested

Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested

The IGNITE-TX study is all about helping people with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome talk to their family members about their risk for cancer and find the best way to get family members tested.


Additional Results on Clinicaltrials.gov Prevention, Detection & Risk + Colorectal Cancer
33 results

Stool Sample Collection Study
NCT ID: NCT06294873 (https://clinicaltrials.gov/study/NCT06294873)

Prospective Collection of Samples to Enable the Development of Natera Screening Assay for Early Cancer Detection
NCT ID: NCT06620627 (https://clinicaltrials.gov/study/NCT06620627)

Impact of Protect Your Colon™ on CRC Screening
NCT ID: NCT05929820 (https://clinicaltrials.gov/study/NCT05929820)

My Best GI Eating Study
NCT ID: NCT05396846 (https://clinicaltrials.gov/study/NCT05396846)

Lynch Syndrome X-Talk of Enteral Mucosa With Immune System
NCT ID: NCT06708429 (https://clinicaltrials.gov/study/NCT06708429)

Aim 3, Optimizing CRC Screening in Patients With Diabetes in Safety-net Primary Care Settings
NCT ID: NCT05785780 (https://clinicaltrials.gov/study/NCT05785780)

Community Partnership for Telehealth Solutions to Counter Misinformation and Achieve Equity
NCT ID: NCT06542835 (https://clinicaltrials.gov/study/NCT06542835)

Blood and Stool Sample Collection in Subjects with a Diagnosis of Colorectal Cancer or Colorectal Lesion: Act Fast
NCT ID: NCT03789162 (https://clinicaltrials.gov/study/NCT03789162)

Shared Decision-making and Colorectal Cancer Screening
NCT ID: NCT04748380 (https://clinicaltrials.gov/study/NCT04748380)

Early Detection of Advanced Adenomas and Colorectal Cancer
NCT ID: NCT06342440 (https://clinicaltrials.gov/study/NCT06342440)

A Prospective, Multi-center, Observational Study for Signal-C Test Evaluation
NCT ID: NCT06059963 (https://clinicaltrials.gov/study/NCT06059963)

Implementation of a ColoRectal Cancer Screening Tool in US Primary Care Practices - Usual Quality Improvement (10 Clinics) vs Normalization Process Theory-Participatory Learning in Action (10 Clinics)
NCT ID: NCT06682650 (https://clinicaltrials.gov/study/NCT06682650)

DNA Evaluation of Fragments for Early Interception - Lung Cancer Training Study (DELFI-L101 Study)
NCT ID: NCT04825834 (https://clinicaltrials.gov/study/NCT04825834)

Reducing Metabolic Dysregulation in Dyads
NCT ID: NCT06117241 (https://clinicaltrials.gov/study/NCT06117241)

Evaluation of Gixam's Performance in a FIT Negative Population
NCT ID: NCT06612281 (https://clinicaltrials.gov/study/NCT06612281)

Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
NCT ID: NCT05732623 (https://clinicaltrials.gov/study/NCT05732623)

Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities
NCT ID: NCT05447923 (https://clinicaltrials.gov/study/NCT05447923)

Impact of Colorectal Cancer and Nutrition Education Program Among Minority Patients With Type 2 Diabetes
NCT ID: NCT05765214 (https://clinicaltrials.gov/study/NCT05765214)

The PRIME-CRC Trial to Promote CRC Screening in Rural Communities
NCT ID: NCT04313114 (https://clinicaltrials.gov/study/NCT04313114)

Understanding Patient Preference on Colorectal Cancer Screening Options-PSU
NCT ID: NCT06444542 (https://clinicaltrials.gov/study/NCT06444542)

Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
NCT ID: NCT05694559 (https://clinicaltrials.gov/study/NCT05694559)

Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas
NCT ID: NCT00843375 (https://clinicaltrials.gov/study/NCT00843375)

Head to Head Mailed Cologuard to Mailed FIT
NCT ID: NCT06173375 (https://clinicaltrials.gov/study/NCT06173375)

A Smartphone-Based Intervention to Improve Colorectal Cancer Screening in African American Men
NCT ID: NCT06052202 (https://clinicaltrials.gov/study/NCT06052202)

Collection of Samples USOPTIVAL Study
NCT ID: NCT04792684 (https://clinicaltrials.gov/study/NCT04792684)

Comparison of Contrast Agents in Liver MR for the Detection of Hepatic Metastases
NCT ID: NCT04973007 (https://clinicaltrials.gov/study/NCT04973007)

IMProving Adherence to Colonoscopy Through Teams and Technology
NCT ID: NCT06191185 (https://clinicaltrials.gov/study/NCT06191185)

Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
NCT ID: NCT01060371 (https://clinicaltrials.gov/study/NCT01060371)

The Genomic Medicine at VA Study
NCT ID: NCT04331535 (https://clinicaltrials.gov/study/NCT04331535)

A Study of Using Social Networks to Encourage Three Peers to Complete Screening for Colorectal Cancer
NCT ID: NCT05793593 (https://clinicaltrials.gov/study/NCT05793593)

Eliminating Barriers to Colorectal Cancer Screening Using Rapid Cycle Testing: A Pilot Study
NCT ID: NCT05524428 (https://clinicaltrials.gov/study/NCT05524428)

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients, CORAL Study
NCT ID: NCT05410977 (https://clinicaltrials.gov/study/NCT05410977)

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
NCT ID: NCT05612347 (https://clinicaltrials.gov/study/NCT05612347)


About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.