Featured Studies Results

Research Study on the Genetics of Breast Cancer

Surveys, Registries, Interviews
This population-based research study aims to enroll at least 10,000 people aged 18 and older who live in the United States. A diagnosis of cancer is NOT required. Participants may receive information about their genetic ancestry for free.

Pancreatic Cancer Screening Study (CAPS5)

Clinicaltrials.gov identifier:
NCT02000089

Prevention
Screening study for people at high risk for pancreatic cancer

Vaccines for Pancreatic Cancer After Chemotherapy

Clinicaltrials.gov identifier:
NCT05111353

Treatment
Vaccine study for people diagnosed with pancreatic cancer

PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease

Clinicaltrials.gov identifier:
NCT04472338

Prevention
Screening study for people with a mutation linked to prostate cancer risk

Ethical Challenges and Best Practices in End-of-Life Care

Surveys, Registries, Interviews
Interview of palliative care patients and/or their adult family members who have been offered and involved in genetic testing or counseling

Understanding the Cancer Journey: A Survey of Patient Experiences and Emotional Impact

Surveys, Registries, Interviews
Online survey for people diagnosed with breast, colorectal, gastric or prostate cancer within the past twenty years

The DETECT Study: Detecting Endometrial Cancer in Tampons

Clinicaltrials.gov identifier:
NCT03538665

Prevention
Early detection of endometrial cancer in women over 45 years of age who are undergoing hysterectomy surgery at the University of Alabama

Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05419011

Prevention
Testing a combination of vaccines for cancer prevention in Lynch syndrome

Effectiveness of Lymph Node Mapping to Reduce the Risk of Swelling in the Legs in Patients with Stage I Endometrial Cancer

Clinicaltrials.gov identifier:
NCT05646316

Treatment
People with stage I endometrial cancer who are having a hysterectomy

Roadmap to Parenthood: A Study about Fertility and Family-Building After Cancer

Clinicaltrials.gov identifier:
NCT06050135

Surveys, Registries, Interviews
A survey for people aged 18-45, assigned female at birth, and history of a cancer diagnosis

Registry to Discover New Treatments and Developmental Processes of Colorectal and Endometrial Cancer in Patients with Hereditary Cancer

Clinicaltrials.gov identifier:
NCT06096688

Surveys, Registries, Interviews
Study to collect and save data, cancer samples, and cancer family health histories from people who screen for colorectal endometrial cancer

The Phoenix Trial: Cemiplimab for Patients with Localized dMMR Colon Cancer

Clinicaltrials.gov identifier:
NCT05961709

Treatment
This study will examine how well Cemiplimab works for patients with localized colon cancer who have dMMR

Exploring the Attitudes of Those Who Tested Positive for an Adult-Onset Cancer Predisposition as a Minor

Surveys, Registries, Interviews
Survey and interview for people who tested positive for an adult-onset cancer predisposition as a minor

Screening Study for Men at High Genetic Risk for Prostate Cancer

Clinicaltrials.gov identifier:
NCT03805919

Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation

Using ctDNA for Earlier Detection and Treatment of Recurrence or Spread after Treatment for Stage 3 Colon Cancer

Clinicaltrials.gov identifier:
NCT03803553

Treatment
Monitoring and treatment study for people who completed treatment for stage 3 colon cancer

Exploring How People of Caribbean Descent Share Information About Their Genetic Mutations with Family Members

Surveys, Registries, Interviews
Survey and interview for people of Caribbean descent who tested positive for a genetic mutation linked to cancer.

Treatment of HER2-positive Colorectal Cancer as First Line Treatment in the Metastatic Setting

Clinicaltrials.gov identifier:
NCT05253651

Treatment
People with HER2-positive colorectal cancer who have not yet received treatment in the metastatic setting

Study of Colorectal Cancer and Genetics in Hispanic and Latino People (ENLACE Study)

Treatment
Hispanic and Latino people diagnosed with colorectal cancer

Pancreatic Cancer Early Detection for People at High Risk

Clinicaltrials.gov identifier:
NCT04970056

Prevention
Registry and biobank for high risk people undergoing pancreatic cancer screening

Early Detection of Colorectal Cancer for People with Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05410977

Prevention
People with Lynch Syndrome at risk for colon cancer

Screening in Men at High Risk of Developing Prostate Cancer

Clinicaltrials.gov identifier:
NCT05608694

Prevention
Screening using MRI for men at risk of developing prostate cancer

My Best GI Eating Study

Clinicaltrials.gov identifier:
NCT05396846

Prevention
Diet and weight loss study for people who are overweight and at increased risk of colorectal cancer

Registry to Promote Health Equity for People of African Ancestry with Breast or Prostate Cancer

Clinicaltrials.gov identifier:
NCT05754658

Surveys, Registries, Interviews
This is a registry for people of African ancestry who have breast or prostate cancer

Survey about Motivations and Barriers to Talking with Family Members about Inherited Cancer Risk

Surveys, Registries, Interviews
Survey for people with an inherited gene mutation

Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome

Clinicaltrials.gov identifier:
NCT05411718

Prevention
Prevention study for people with Lynch syndrome

Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Cancer Survivors

Clinicaltrials.gov identifier:
NCT05056077

Quality of Life
Bladder, breast, colon, endometrial, kidney (renal cell carcinoma), ovarian, prostate, or rectal cancer

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Clinicaltrials.gov identifier:
NCT05129605

Prevention
People at high risk for prostate cancer due to an inherited mutation

Blood Markers of Early Pancreas Cancer

Clinicaltrials.gov identifier:
NCT03568630

Prevention
Observational study for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk

Upright MRI for Prostate Cancer Screening

Clinicaltrials.gov identifier:
NCT03474913

Prevention
Screening for prostate cancer using upright MRI

Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed

Clinicaltrials.gov identifier:
NCT03231891

Surveys, Registries, Interviews
People with an inherited mutation or cancer in the family

Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor

Clinicaltrials.gov identifier:
NCT03607890

Treatment
Solid tumors that are MSI-High and resistant to prior immunotherapy

Chemotherapy, Bevacizumab, and/or Atezolizumab for dMMR / MSI-H Metastatic Colorectal Cancer (COMMIT Study)

Clinicaltrials.gov identifier:
NCT02997228

Treatment
This is a treatment study is for people with metastatic colorectal cancer

Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families

Prevention
Screening study for women with a BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, PMS2, MLH1, MSH2, MSH6, or EPCAM mutation

Nivolumab, Nivolumab Plus Ipilimumab, or Chemotherapy for Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (CheckMate 8HW)

Clinicaltrials.gov identifier:
NCT04008030

Treatment
People with metastatic colorectal cancer that is MSI-High

Pancreatic Cancer Screening Study for High Risk People

Clinicaltrials.gov identifier:
NCT03250078

Prevention
Screening study to detect pancreatic cancer and precancer in people with either a strong family history of pancreatic cancer, or an inherited mutation associated with pancreatic cancer risk

ELLIE's Project

Quality of Life
A survey to gain a better understanding of the baseline lifestyle factors related to nutrition and physical activity in people with a hereditary cancer gene mutation.