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Featured Studies Results

Vaccine for People at High Risk for Pancreatic Cancer

https://www.facingourrisk.org/research-clinical-trials/study/365 /vaccine-for-those-at-high-risk-of-developing-pancreatic-cancer

Clinicaltrials.gov identifier:
NCT05013216 (https://clinicaltrials.gov/show/NCT05013216)

Prevention
Phase 1 pancreatic cancer prevention study for people at high risk

Comparing an Investigational Targeted Drug AZD5335 to Standard Treatments in People With Platinum‑Resistant Ovarian Cancer (TREVI‑OC‑01)

https://www.facingourrisk.org/research-clinical-trials/study/371 /comparing-an-investigational-targeted-drug-azd5335-to-standard-treatments-in-people-with-platinumresistant-ovarian-cancer-trevioc01

Clinicaltrials.gov identifier:
NCT07218809 (https://clinicaltrials.gov/show/NCT07218809)

Treatment
Phase 3 treatment study for platinum-resistant ovarian cancer

Using a Blood Test to Detect Early Cancer Recurrence After Treatment (ORACLE)

https://www.facingourrisk.org/research-clinical-trials/study/372 /using-a-blood-test-to-detect-early-cancer-recurrence-after-treatment-oracle

Clinicaltrials.gov identifier:
NCT05059444 (https://clinicaltrials.gov/show/NCT05059444)

Treatment
Post-treatment study to monitor for recurrence

Exploring How BRCA+ Previvors Experience Joy

https://www.facingourrisk.org/research-clinical-trials/study/410 /exploring-how-brca-previvors-experience-joy

Surveys, Registries, Interviews
Survey and interviews about joy and emotions following genetic results for BRCA+ previvors

A Study for Women Having Revision Breast Implant Surgery

https://www.facingourrisk.org/research-clinical-trials/study/402 /a-study-for-women-having-revision-breast-implant-surgery

Clinicaltrials.gov identifier:
NCT05945329 (https://clinicaltrials.gov/show/NCT05945329)

Prevention
An interventional study for women undergoing revision breast implant surgery

SCREEN-CUP: Menstrual Cup Screening for Endometrial Cancer in Lynch Syndrome

https://www.facingourrisk.org/research-clinical-trials/study/398 /screen-cup-menstrual-cup-screening-for-endometrial-cancer-in-lynch-syndrome

Clinicaltrials.gov identifier:
NCT07220239 (https://clinicaltrials.gov/show/NCT07220239)

Prevention
Screening study for endometrial cancer

An Early Detection and Prevention Study for People with an Increased Risk of Cancer (InAdvance)

https://www.facingourrisk.org/research-clinical-trials/study/385 /an-early-detection-and-prevention-study-for-people-with-an-increased-risk-of-cancer-inadvance

Clinicaltrials.gov identifier:
NCT05463796 (https://clinicaltrials.gov/show/NCT05463796)

Prevention
Study for people at risk of cancer, including previvors, survivors and family members

Genetic Testing for Cancer Risk for Black Families in Texas

https://www.facingourrisk.org/research-clinical-trials/study/396 /genetic-testing-for-cancer-risk-for-black-families-in-texas

Clinicaltrials.gov identifier:
NCT05694559 (https://clinicaltrials.gov/show/NCT05694559)

Prevention
Study to improve genetic counseling and testing to Black families in Texas

Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk Reduction

https://www.facingourrisk.org/research-clinical-trials/study/395 /low-dose-tamoxifen-with-or-without-omega-3-fatty-acids-for-breast-cancer-risk-reduction

Clinicaltrials.gov identifier:
NCT06195306 (https://clinicaltrials.gov/show/NCT06195306)

Prevention
Phase 2 study for overweight postmenopausal women at increased risk for breast cancer

Comparing an Experimental Drug Puxi-Sam to Standard Chemotherapy for Metastatic Endometrial Cancer (Bluestar‑Endometrial01)

https://www.facingourrisk.org/research-clinical-trials/study/370 /comparing-an-experimental-drug-puxi-sam-with-standard-chemotherapy-for-metastatic-endometrial-cancer-bluestarendometrial01

Clinicaltrials.gov identifier:
NCT07044336 (https://clinicaltrials.gov/show/NCT07044336)

Treatment
Phase 3 treatment study for metastatic endometrial cancer

Treating Advanced Solid Tumors with Targeted Therapies Called RAS(ON) Inhibitors Combined With the Targeted Immunotherapy Ivonescimab

https://www.facingourrisk.org/research-clinical-trials/study/408 /treating-advanced-solid-tumors-with-the-rason-inhibitor-daraxonrasib-combined-with-a-targeted-immunotherapy-ivonescimab

Clinicaltrials.gov identifier:
NCT07397338 (https://clinicaltrials.gov/show/NCT07397338)

Treatment
Phase 1/2 treatment study for solid tumors with a RAS mutation

The EASE Study: Helping People with Advanced Cancer Cope with Fear of Cancer Progression

https://www.facingourrisk.org/research-clinical-trials/study/413 /the-ease-study-helping-people-with-advanced-cancer-cope-with-fear-of-cancer-progression

Clinicaltrials.gov identifier:
NCT07636200 (https://clinicaltrials.gov/show/NCT07636200)

Quality of Life
Quality of life study for people with advanced cancer experiencing anxiety

Comparing a New Drug, Palazestrant, to Standard Treatment for Advanced Breast Cancer

https://www.facingourrisk.org/research-clinical-trials/study/387 /comparing-a-new-drug-palazestrant-to-standard-treatment-for-advanced-breast-cancer

Clinicaltrials.gov identifier:
NCT06016738 (https://clinicaltrials.gov/show/NCT06016738)

Treatment
Phase 3 study for ER-positive, HER2-negative advanced or metastatic breast cancer

Perceptions of Gastric Cancer Risk and Attitudes Toward Endoscopic Surveillance in People with CDH1 or CTNNA1 Mutations

https://www.facingourrisk.org/research-clinical-trials/study/390 /perceptions-of-gastric-cancer-risk-and-attitudes-toward-endoscopic-surveillance-in-people-with-cdh1-or-ctnna1-mutations

Surveys, Registries, Interviews
Online survey about gastric cancer risk and medical decision-making for people with an inherited CDH1 or CTNNA1 pathogenic variant

Treating Advanced Solid Tumors with a KRAS G12C Mutation Using Targeted Therapies Called RAS(ON) Inhibitors

https://www.facingourrisk.org/research-clinical-trials/study/409 /treating-advanced-solid-tumors-with-a-kras-g12c-mutation-using-targeted-therapies-called-rason-inhibitors

Clinicaltrials.gov identifier:
NCT06128551 (https://clinicaltrials.gov/show/NCT06128551)

Treatment
Phase 1/2 treatment study for advanced colorectal, pancreatic or lung cancer with a KRAS G12C mutation

Testing a KRAS Vaccine with Immunotherapy for Advanced Pancreatic and Colorectal Cancers with MMR‑Proficient (MMR‑p) Tumors

https://www.facingourrisk.org/research-clinical-trials/study/384 /testing-a-kras-vaccine-with-immunotherapy-for-advanced-pancreatic-and-colorectal-cancer

Clinicaltrials.gov identifier:
NCT06411691 (https://clinicaltrials.gov/show/NCT06411691)

Treatment
Phase 1b treatment study for previously-treated pancreatic or colorectal cancer with a KRAS mutation

A Study of Fallopian Tube Removal with Delayed Ovary Removal to Lower Ovarian Cancer Risk (TUBA-WISP-II)

https://www.facingourrisk.org/research-clinical-trials/study/404 /

Clinicaltrials.gov identifier:
NCT04294927 (https://clinicaltrials.gov/show/NCT04294927)

Prevention
Prevention study for women at high risk for ovarian cancer

Testing a Combination of Immunotherapy and a Vaccine in People With Advanced Pancreatic or Lung Cancer

https://www.facingourrisk.org/research-clinical-trials/study/373 /testing-a-combination-treatment-with-an-anti-cd38-antibody-kras-vaccine-and-anti-pd-1-antibody-in-people-with-advanced-pancreatic-or-lung-cancer

Clinicaltrials.gov identifier:
NCT06015724 (https://clinicaltrials.gov/show/NCT06015724)

Treatment
Phase 2 treatment study for advanced pancreatic and lung cancer

About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.