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Featured Studies Results

A Study of Talazoparib With or Without Enzalutamide in People With Prostate Cancer Who Have Previously Received Abiraterone or Darolutamide (TALENT)

https://www.facingourrisk.org/research-clinical-trials/study/425 /a-study-of-talazoparib-with-or-without-enzalutamide-in-people-with-prostate-cancer-who-have-previously-received-abiraterone-or-darolutamide-talent

Clinicaltrials.gov identifier:
NCT06844383 (https://clinicaltrials.gov/show/NCT06844383)

Treatment
Phase 2 study for metastatic castration-resistant prostate cancer with an HRR mutation

ERADICATE: Hormone and Targeted Therapy for HR+/HER2-Low Advanced Breast Cancer

https://www.facingourrisk.org/research-clinical-trials/study/447 /eradicate-hormone-and-targeted-therapy-for-hrher2-low-advanced-breast-cancer

Clinicaltrials.gov identifier:
NCT07198724 (https://clinicaltrials.gov/show/NCT07198724)

Treatment
Phase Ib/II study of hormone and targeted therapy for advanced breast cancer

Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk Reduction

https://www.facingourrisk.org/research-clinical-trials/study/443 /low-dose-tamoxifen-with-or-without-omega-3-fatty-acids-for-breast-cancer-risk-reduction

Clinicaltrials.gov identifier:
NCT06195306 (https://clinicaltrials.gov/show/NCT06195306)

Prevention
Phase 2 prevention study for postmenopausal women ages 45–74 at increased risk for breast cancer

IGNITE-TX - Identifying Individuals for Genetic Testing for Familial Cancer

https://www.facingourrisk.org/research-clinical-trials/study/266 /helping-people-with-a-genetic-mutation-in-brca1-brca2-or-lynch-syndrome-talk-to-their-family-members-about-their-risk-for-cancer-and-find-the-best-way-to-get-family-members-tested

Clinicaltrials.gov identifier:
NCT07318363 (https://clinicaltrials.gov/show/NCT07318363)

Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested

Research Study on the Genetics of Breast Cancer

https://www.facingourrisk.org/research-clinical-trials/study/317 /research-study-on-the-genetics-of-breast-cancer

Clinicaltrials.gov identifier:
NCT06773897 (https://clinicaltrials.gov/show/NCT06773897)

Surveys, Registries, Interviews
A registry for anyone aged 18 and older who lives in the United States

ShareForCures®: Komen's People-Powered, Data-Driven Breast Cancer Research Registry

https://www.facingourrisk.org/research-clinical-trials/study/295 /shareforcures-susan-g-komens-people-powered-data-driven-breast-cancer-research-registry

Clinicaltrials.gov identifier:
NCT05654246 (https://clinicaltrials.gov/show/NCT05654246)

Surveys, Registries, Interviews
Registry for anyone diagnosed with breast cancer

FIT Testing for Colorectal Cancer Screening in People with Lynch Syndrome

https://www.facingourrisk.org/research-clinical-trials/study/418 /fit-testing-for-colorectal-cancer-screening-in-people-with-lynch-syndrome

Clinicaltrials.gov identifier:
NCT06898996 (https://clinicaltrials.gov/show/NCT06898996)

Prevention
Colon cancer screening study for people with Lynch syndrome

The ZERO Prostate Cancer BEACON (Barriers, Education, Awareness, Care, Outcomes, and Needs) Survey

https://www.facingourrisk.org/research-clinical-trials/study/446 /the-prostate-cancer-beacon-barriers-education-awareness-care-outcomes-and-needs-survey

Surveys, Registries, Interviews
BEACON is a survey designed to build a comprehensive understanding of the state of prostate cancer awareness and care from the perspectives of men at risk, patient/survivors, caregivers, and healthcare professionals 21 and older.

Virtual Exercise Classes for Adult Cancer Survivors (SURGE)

https://www.facingourrisk.org/research-clinical-trials/study/445 /virtual-exercise-classes-for-adult-cancer-survivors-surge

Clinicaltrials.gov identifier:
NCT07290309 (https://clinicaltrials.gov/show/NCT07290309)

Quality of Life
Exercise study for people diagnosed within the past 5 years

Using a Computer Model to Identify Treatment Options in Advanced Metastatic Breast Cancer (SYNTHESIS-Breast)

https://www.facingourrisk.org/research-clinical-trials/study/438 /using-a-computer-model-to-identify-treatment-options-in-advanced-metastatic-breast-cancer-synthesis-breast

Clinicaltrials.gov identifier:
NCT07067138 (https://clinicaltrials.gov/show/NCT07067138)

Treatment
Treatment study for people with metastatic breast cancer

Previvors’ Perceptions of Preimplantation Genetic Testing (PGT-M) After a Cancer Predisposition Diagnosis

https://www.facingourrisk.org/research-clinical-trials/study/435 /previvors-perceptions-of-preimplantation-genetic-testing-pgt-m-after-a-cancer-predisposition-diagnosis

Surveys, Registries, Interviews
Interview for eligible previvors

Treating Advanced MSI-High or dMMR Cancers Using the Targeted Therapy MOMA-341 Given Alone or In Combination with Standard Therapies

https://www.facingourrisk.org/research-clinical-trials/study/356 /treating-advanced-msi-high-or-dmmr-cancers-using-the-targeted-therapy-moma-341-given-alone-or-in-combination-with-standard-therapies

Clinicaltrials.gov identifier:
NCT06974110 (https://clinicaltrials.gov/show/NCT06974110)

Treatment
Treatment study for people with advanced or metastatic cancers

Family Communication After Genetic Testing for Colorectal Cancer

https://www.facingourrisk.org/research-clinical-trials/study/437 /family-communication-after-genetic-testing-for-colorectal-cancer

Clinicaltrials.gov identifier:
NCT07143487 (https://clinicaltrials.gov/show/NCT07143487)

Prevention
Family communication study after colorectal cancer diagnosis

Understanding Risk Factors for Stomach Cancer in People with Inherited Mutations

https://www.facingourrisk.org/research-clinical-trials/study/332 /understanding-risk-factors-for-stomach-cancer-in-people-with-inherited-mutations

Surveys, Registries, Interviews
Online survey on stomach cancer risk for people with an inherited mutation in genes that are linked to an increased risk of cancer

REKINDLE: Your Ability to Cope With a Life-Changing Medical Diagnosis

https://www.facingourrisk.org/research-clinical-trials/study/423 /rekindle-your-ability-to-cope-with-a-life-changing-medical-diagnosis

Clinicaltrials.gov identifier:
NCT07002034 (https://clinicaltrials.gov/show/NCT07002034)

Quality of Life
Study for those experiencing mental health struggles due to a diagnosis of cancer or other medical illness

Testing COM701 Maintenance Treatment to Delay Cancer Growth After Platinum Chemotherapy for Ovarian Cancer That Has Come Back

https://www.facingourrisk.org/research-clinical-trials/study/381 /testing-com701-maintenance-treatment-to-delay-cancer-growth-after-platinum-chemotherapy-for-ovarian-cancer-that-has-come-back

Clinicaltrials.gov identifier:
NCT06888921 (https://clinicaltrials.gov/show/NCT06888921)

Treatment
Study for relapsed platinum-sensitive ovarian cancer

A New Drug, DT2216, Combined With Paclitaxel for Recurrent Platinum-Resistant Ovarian Cancer

https://www.facingourrisk.org/research-clinical-trials/study/429 /a-new-drug-dt2216-combined-with-paclitaxel-for-recurrent-platinum-resistant-ovarian-cancer

Clinicaltrials.gov identifier:
NCT06964009 (https://clinicaltrials.gov/show/NCT06964009)

Treatment
Phase 1b study for people with recurrent platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer

Multi-Cancer Detection Blood Tests in Adults Without Cancer: Vanguard Study

https://www.facingourrisk.org/research-clinical-trials/study/394 /multi-cancer-detection-blood-tests-in-adults-without-cancer-vanguard-study

Clinicaltrials.gov identifier:
NCT06995898 (https://clinicaltrials.gov/show/NCT06995898)

Prevention
A study testing two multi-cancer detection blood tests in people who do not have cancer

About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.