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Hereditary Cancer and Genetic Testing

General information for people with inherited  mutations

Both men and women can carry a mutation in the  gene. 

People with an inherited mutation in  have increased risk for certain cancers. See our Cancer Risk section for more information. There are guidelines for screening and prevention for certain cancers in people with a  mutation. Clinical trials may also be available for people who test positive for a  mutation. See our Risk Management section for more information about screening options in people with  mutations.

People with a  mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials. Visit our Cancer Treatment section for more information about treatment clinical trials for people with a  mutation.

Inheriting two mutations in —one from each parent—causes a rare disease known as Fanconi anemia. See our Other Considerations section for more information about this disease.

 mutations can be found in people of every race and ethnicity. However, people of Eastern European (Ashkenazi) Jewish ancestry are more likely to have an inherited  mutation than people who are not of Jewish descent.

The name stands for "Breast Cancer 2." The  gene is located on chromosome 13.  helps to repair damaged .

Last updated March 13, 2022

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FORCE offers many peer support programs for people with inherited mutations. 

updated: 08/06/2022