Advocacy

FORCE advocates for families facing hereditary breast and ovarian cancer in areas such as access to care, research funding, insurance, and privacy.

Advocacy > Advocacy Accomplishments


Newsflash

9/27/2019
FORCE joined over two dozen orgs in urging CMS to reconsider the 14-day Rule, which has created delays in patients receiving test results.

9/24/2019
Signed onto a letter urging the President to waive out-of-pocket costs for seniors on Medicare who have precancerous polyps removed during a screening colonoscopy.

9/3/2019
We joined over 50 orgs representing patients, advocates, caregivers, researchers, and physicians to express support for appointment of Norman Sharpless as FDA Commissioner.

7/26/2019
FORCE is supporting legislation (H.R. 4078) to reauthorize and increase funding for the Breast Cancer Education and Awareness Requires Learning Young Act (EARLY) Act.

FDA Approves First PARP Inhibitor: A Win for the BRCA Community

Treatments & Therapies

FORCE was one of a handful of advocacy organizations to testify in favor of accelerated approval of olaparib at the FDA hearing of the Oncology Drug Advisory Committee (ODAC) in June 2014. ODAC voted against approval at the conclusion of that meeting and early word from the FDA was that more research was needed before it would approve this therapy. The BRCA cancer community is grateful that the FDA reconsidered and approved this treatment.

PARP inhibitors are “targeted therapy” drugs that target tumors based on their unique biology. Developing these “smart” drugs requires a greater understanding of how cancer cells differ from other cells, and identifying cellular vulnerabilities. Targeted therapy uses specific treatments to attack the weaknesses of certain cancers based on their cellular genetic traits. PARP inhibitors block an enzyme used by cells to repair damage to their DNA. In people with BRCA mutations, PARP inhibitors may work by keeping cancer cells from repairing themselves once they’ve been damaged by chemotherapy, while sparing healthy cells.

Despite early positive findings, PARP inhibitor research almost came to a halt several years ago due in part to the challenge of studying drugs that may only benefit small subsets of a larger cancer patient population. Fortunately, thanks to champions within the scientific, advocacy and biotech communities, this important research continued. FDA approval of Lynparza is the culmination of these ongoing efforts, and hopefully only the beginning for this promising class of drugs. See our blog about this decision and read our article on this milestone.

PARP inhibitors are being studied as treatment for a variety of BRCA and BRCA-like cancers. FORCE continues to support these efforts via encouraging genetic testing of those diagnosed with cancer and supporting clinical trial enrollment.  

FORCE:Facing Our Risk of Cancer Empowered