- This model only takes into account single nucleotide polymorphisms that are believed to increase cancer risk. It does not include known disease causing genetic mutations, such as those in BRCA.
- This model has not been clinically validated, which means it is not ready to be used in medical decision-making.
- The model looked at risk factors in White women. More work would need to be done to see if the model also applies to women of other ethnicities.
- There are known links between diet and lifestyle factors and breast cancer risk and incorporating these factors into risk models is an important goal, however, much more research needs to be done before this model could be applied in clinical setting to estimate women's risk.
Strength of Science: Medium
- This study is a good step forward in developing breast cancer risk prediction models. Many of the models used do not include a lot of the now known breast cancer risk increasing factors.
- More work needs to be done to confirm the findings of this model. The researchers did not collect their own data for their model; therefore, they could not include all of the known breast cancer risk increasing factors.
Research Timeline: Human Research
- Although this model is based on research in humans, much more research will be needed before this model can be applied in the clinical setting.