- This study is relevant for breast cancer survivors with an inherited mutation and breast cancer survivors who develop treatment-related leukemia.
- Treatment-related leukemia is very rare, even among people with inherited mutations.
- More research will be needed to determine who is at most risk for treatment-related leukemia and steps that can be taken to prevent it.
Strength of Science: Medium
- This was a relatively small study looking at a rare event. This study does not conclusively say that mutation carriers are at increased risk of developing therapy-related leukemia. Larger studies will be needed in order to prove a link between inherited mutations and treatment-related leukemia.
- Several people tested positive for an inherited mutation in the gene TP53. People with inherited mutations in TP53 are already at higher risk for leukemia.
- The study did not compare people with mutations who developed leukemia to people with mutations who did not develop leukemia. This type of research will be important to determine what the risk factors are for treatment-related leukemia in people with inherited mutations.
Research Timeline: Early Human Study
- This was a relatively small study looking at treatment-related leukemia in people.