- This is a study done solely in mice. It is exceptionally well-designed, with well-described controls and clear experimental conditions. The sample size of experiments is appropriate to the aim of the study.
- The experiments address the issue in mice; the effect on humans, which was not the intent of these experiments, remains to be answered. The statistical analysis was sound and appropriate for the study.
- This study is relevant for breast cancer survivors, even though it is only early research in mice. Additional follow-up studies in mice are needed to confirm the interpretation of these findings. Clinical studies are needed to address whether the findings are relevant for humans.