- The majority of the results presented in this study were from mouse models of breast cancer.
- This study evaluated 20 ER-positive/HER2-negative breast cancers both pre- and post- neoadjuvant chemotherapy. This is a very small number of only one breast cancer subtype. The results cannot be assumed to apply to all breast cancer subtypes.
- More research needs to be done on a much larger sample of breast cancers to validate the preliminary observations of this study.
- Only mouse controls were evaluated in this study. No human control samples were evaluated.