Removing ovaries before age 50 may increase the risk of chronic conditions for some women
https://www.facingourrisk.org/XRAY/ovary-removal-and-chronic-disease
Full article: https://www.mayoclinicproceedings.org/article/S0025-6196(16)30447-5/abstract
Removal of ovaries and fallopian tubes prevents ovarian cancer, but it may come with other health risks. Experts recommend removal of ovaries and fallopian tubes in women at high risk for ovarian cancer due to inherited mutations in BRCA or other genes linked to ovarian cancer risk. For these high-risk women the benefit of ovarian cancer prevention outweighs the risk of long-term complications. Based on a recent study, some researchers feel that for women who are not at increased risk for cancer, the risk for some chronic conditions is too high to consider removal of both ovaries. (11/1/16)
Questions To Ask Your Health Care Provider
- I I had breast cancer before age 50. Should I consider genetic testing to see if I am at increased risk of ovarian cancer?
- How do I know if I am at increased risk for ovarian cancer?
- I tested negative for a mutation in BRCA despite having breast cancer before age 50. Should I be concerned about my ovarian cancer risk?
- What are my options for preventing ovarian cancer or detecting it early?
- I had my ovaries removed to reduce my risk for ovarian cancer. What steps can I take to prevent or reduce long-term complications?
- Can you refer me to a menopause expert?
Open Clinical Trials
The following are studies on menopause and menopause management for survivors and previvors:
- NCT04439370: Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women. This study will look at the effects of early menopause on blood pressure.
- NCT03572153: A Mind-Body Intervention for Hot Flash Management. The main goal of this study is to test whether self-administered hypnosis can be used to reduce hot flashes more than self-administered white noise hypnosis over 6 weeks of home practice.
- NCT04821141: Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens. Women at increased risk for breast cancer who experience hot flashes will receive bazedoxifene plus conjugated estrogens (similar to the drug Duavee) for 6 months or a control (no drug). Researchers will measure breast density with mammography and needle biopsy that looks at biomarkers.
- NCT06112756: A Study to Learn About How Elinzanetant Works and How Safe it is in Women Having Sleep Disturbances Associated with Menopause (NIRVANA). The study treatment Elinzanetant is being studied to treat symptoms like hot flashes which are caused by hormonal changes associated with menopause. It may block the activity of a protein that has been found to contribute to sleep disturbances.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.