Are mutations in BRIP1, BARD1, PALB2, and NBN associated with an increased risk for ovarian cancer?
https://www.facingourrisk.org/XRAY/mutations-and-ovarian-cancer-risk
Full article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643629/
Many women who have genetic testing for an inherited mutation find that they do not carry a mutation in BRCA1 or BRCA2 despite their personal and family history of breast and/or ovarian cancer. Panel tests look for mutations in other genes associated with increased cancer risk. However, the cancer risk for people with mutations in some of these other genes is not yet known. This study looks at whether mutations in four genes, BRIP1, BARD1, PALB2, and NBN, are associated with an increased risk for ovarian cancer. The researchers found that BRIP1 mutation carriers have about a 6% risk of developing ovarian cancer by age 80. (02/09/16)
Questions To Ask Your Health Care Provider
- I have a mutation in BRIP1, BARD1, PALB2, or NBN. How should I be cared for?
- I have a mutation in BRIP1, should I have surgery to remove my ovaries and fallopian tubes?
- What is the ideal age for risk-reducing removal of the ovaries and fallopian tubes.
- I tested negative for mutations in BRCA1/2 despite my personal and/or family cancer history. Should I consider panel testing to see if I have a mutation in other genes that would increase my cancer risk?
- Can you refer me to a genetic counselor?
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.