Study: Do BRCA mutations affect fertility?


This article is most relevant for:
Women with a BRCA mutation who want to become pregnant

This article is also relevant for:

Checked Breast cancer survivors

Checked People with a genetic mutation linked to cancer risk

Checked Previvors

Checked Women under 45

Checked Special populations: Women considering childbearing


Be a part of XRAY

Relevance: Medium

Relevance

Strength of Science: Medium

Strength of Science

Research Timeline: Human Research

Research Timeline

Rating Details

Read the article

Printer Friendly Page

Age affects fertility. As women age, their ovaries release eggs that are not as healthy as those released in younger women. Fewer eggs are released each menstrual cycle as women age, making it harder for older women to become pregnant. Are women with BRCA mutations less fertile? Previous research suggested that BRCA mutations might affect women's fertility as she ages. A recent study found that BRCA1 mutation carriers may have slightly lower fertility than women without the same mutation, but more research is needed before this finding is useful for medical decision-making. (5/24/16)

Contents

At a glance                  Questions for your doctor
Findings               In-depth                
Clinical trials Limitations
Guidelines Resources and references


STUDY AT A GLANCE

This study is about:

Whether having a BRCA mutation affects ovarian reserve, which in general describes the capacity of ovaries to provide eggs that will ultimately result in a successful pregnancy.

Why is this study important?

"Ovarian reserve"—the amount of healthy eggs a woman has—is affected by her age. The older a woman gets the fewer healthy eggs she has to release from her ovariy each month. Because of this, age is often a factor in fertility and family planning. If faving a BRCA mutation also affects fertility, this would be more important information for women to take into account for family planning.

Study findings: 

  1. BRCA1 mutation carriers had lower ovarian reserve, as measured by the concentration of the hormone AMH, than women who did not have BRCA1 mutations.
  2. There was no difference in ovarian reserve between women with BRCA2 mutations and women without mutations in BRCA.   

What does this mean for me?

While the association between BRCA1 mutation carriers and lower ovarian reserve adds to previous data, more research will need to be done to prove this link. The actual difference in ovarian reserve found in this study was relatively small. Women with BRCA mutations may want to consult with both genetics experts and fertility experts to coordinate their family planning and their plans for cancer screening and preventive surgeries. BRCA mutation carriers who have been diagnosed with cancer should request a referral to a fertility expert if they are concerned about the affects of treatment on their ability to conceive.  

Expert Guidelines

The National Comprehensive Cancer Network (NCCN) has guidelines for oncologists treating young women with cancer who are concerned about their fertility:

  • Discuss fertility implications before and after treatment.
  • Discuss contraception after treatment.
  • Discuss specific methods for fertility preservation such as freezing embryos, eggs, or ovarian tissue.
  • Some research has looked at whether medications to suppress menstruation may protect the ovaries during treatment with chemotherapy. 

Questions To Ask Your Health Care Provider

  • I am a BRCA1 mutation carrier. What factors should I take into account when deciding when I should have children?
  • I am having trouble conceiving. Are their options available to help?
  • How do fertility treatments affect my cancer risk?
  • How might cancer treatment affect my fertility?

Open Clinical Trials

 

 

IN DEPTH REVIEW OF RESEARCH

Study background:

A woman is born with all of the eggs she will have throughout her life. Each month during her menstrual cycle, she releases one egg and in general, the healthier eggs are released when she is younger and the less healthy eggs are released later on. This is often referred to as lower ovarian reserve.  Healthier eggs have a higher chance of resulting in a pregnancy, making it more difficult for women to get pregnant at older ages.

Some studies have suggested that BRCA genes are involved in reproductive aging, while others have not. Kelly-Anne Phillips and colleagues at the Peter MacCallum Cancer Centre in Australia and colleagues published findings in the journal Human Reproduction where they looked at how BRCA status affected ovarian reserve (as measured by concentration of the hormone called AMH (Anti-Müllerian hormone) in the blood.

Researchers of this study wanted to know:

  1. Does having a BRCA1 or BRCA2 mutation result in women having a lower ovarian reserve?

Population(s) looked at in the study:

The researchers used blood samples from 172 BRCA1 mutation carriers and 216 women from families with BRCA1 mutations who did not carry the mutation in their family, as well as 147 BRCA2 mutation carriers and 158 women from families with BRCA1 mutations who did not carry the mutation in their family. These women were between the ages of 25-45, had two intact ovaries and had no personal history of any cancer (except for non-melanoma skin cancer). Researchers measured AMH (Anti-Müllerian hormone) concentrations in the blood, which is a measurement of ovarian reserve as AMH is a hormone produced by eggs and represents a woman’s overall egg pool. AMH is a good measurement of ovarian reserve and is one of the most important tests that fertility specialists use when counseling patients.  

Study findings: 

  1. On average, BRCA1 mutation carriers had lower ovarian reserve as measured by AMH concentrations than women who did not carry BRCA1 mutations.
    • The difference is comparable to a two-year increase, meaning a 35-year old woman who is a BRCA1 carrier and a 37-year old woman who is a non-carrier had similar ovarian reserves.
  2. There was no difference between the average ovarian reserve as measured by AMH concentrations between women with BRCA2 mutations and women without BRCA2 mutations.

Limitations:

The sample size used in this research study was relatively small. While the researchers saw that there was no difference in AMH concentrations between BRCA2 carriers and non-carriers, this may be because there were not enough BRCA2 patients in the study for the researchers to see a difference.  

Conclusions:

While this study suggests an association between BRCA1 mutation status and a lower ovarian reserve, more work needs to be done to confirm this finding, in addition to the BRCA2 finding, as it was a relatively small study. Additionally, because the difference in AMH concentrations between BRCA1 mutation carriers and non-carriers was not large, the authors write “…it is possible that the findings of our study might not translate to clinically relevant fertility implications for younger women, but may be important for the subgroup of BRCA1 mutation carriers who wish to conceive in their late 30s or 40s when fertility is reduced even in the general population.” Young BRCA1 mutation carriers do not need to rush to have children based on these findings alone. However, women in their late 30s and 40s do already have a reduced ovarian reserve due to age—may want to talk to a fertility expert, particularly if they are having trouble conceiving. These experts may suggest trying to conceive at an earlier age or freezing their eggs.

Posted 5/23/16

Share your thoughts on this XRAYS article by taking this brief survey.  

Back to XRAY Home

Search XRAY studies and articles

Back to XRAY Home

FORCE:Facing Our Risk of Cancer Empowered