Treating advanced breast cancer with ESR1 mutations shows promise

https://www.facingourrisk.org/XRAY/treating-advanced-breast-cancer-with-ESR1-mutations

Full article: https://www.nejm.org/doi/10.1056/NEJMoa2502929

Treatment with the new hormonal drug camizestrant benefited people with certain advanced breast cancers with a biomarker called an ESR1 mutation. People who participated in the SERENA6 study experienced a longer time before their cancer worsened and had a better quality of life than those who received the standard treatment. This study used a blood test to track changes in the cancer to clarify whether treatment worked before symptoms developed. (posted 2/19/26)

Questions To Ask Your Health Care Provider

Is my breast cancer advanced?
Does my tumor have ESR1 gene mutations?
Will liquid biopsy tests be used to monitor my cancer?
If my treatment stops working, what options are available?
Are there clinical trials that might be an ideal option for me?

About FORCE

FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.