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FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you. XRAY is a reliable source of hereditary cancer research-related news and information.
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1 through 10 of 77

Relevance: High

Strength of Science: High

Research Timeline: Post Approval

Study : Screening for pancreatic cancer detects early-stage disease and improves survival

Most relevant for: People at increased risk for pancreatic cancer because of family history or an inherited mutation.

A research study has shown that screening for pancreatic cancer in people with an inherited mutation or family history was able to detect early-stage pancreatic cancers and improve survival. These results will likely change pancreatic cancer screening guidelines for high-risk individuals (Posted 8/30/22)

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Relevance: Medium-High

Strength of Science: High

Research Timeline: Post Approval

Study : Risk-reducing ovarian cancer surgery and quality of life

Most relevant for: People with an inherited BRCA mutation

People with an inherited BRCA gene mutation are recommended to have surgery to remove their ovaries before the age of natural menopause to reduce their risk of ovarian cancer.  This surgery can cause short-term and long-term effects. This study assesses the quality of life among people who have their fallopian tubes surgically removed and later have their ovaries removed compared to people who have their ovaries and fallopian tubes removed at the same time.  (Posted 7/26/22)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Metastatic prostate cancer cases increased as screening use declined

Most relevant for: People who are concerned about their own or their loved one’s risk of prostate cancer

The number of people diagnosed with metastatic prostate cancer increased following a change in recommendations around the use of routine prostate cancer screening. (posted 6/13/22)

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Relevance: Medium-High

Article : Breast cancer risk for transgender men with inherited mutations

Most relevant for: Transgender men with an inherited mutation

There is little information related to the risks and treatment options for transgender men and nonbinary people who are at high-risk for breast cancer due to an inherited BRCA1 or BRCA2 mutation. We review an expert viewpoint on the implications of a BRCA mutation for transgender men undergoing breast removal as part of their gender-affirming care plan. (posted 5/19/22)

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Relevance: Medium-High

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : New tool to predict breast cancer risk for Black women

Most relevant for: Black women in the U.S.

An important part of making decisions about breast cancer screening and prevention is knowing your breast cancer risk. Specific tools are used to identify people who would benefit from early and/or additional screening and chemoprevention or those who would most benefit from genetic counseling and testing. Because these tools were developed using data mostly from white women, they are unable to predict cancer risk as well for Black women. To begin to address these gaps, researchers developed a new tool specifically designed to predict breast cancer risk for Black women. This tool has been shown to work well, especially for younger Black women. (posted 3/22/2022)

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Relevance: High

Quality of Writing: Medium-High

Research Timeline: Post Approval

Article : Chris Evert's ovarian cancer diagnosis highlights the importance of genetic counseling and testing

Most relevant for: People with genetic test result called a VUS

Tennis star Chris Evert shared her story about a change in her sister's genetic test results that led Ms. Evert to have genetic testing and her decision to have her ovaries removed to lower her cancer risk. Ovarian cancer was found at the time of Ms. Evert’s surgery, but fortunately, it was caught early. Her story highlights the importance of genetic counseling, testing and post-testing follow-up with experts. (Posted 2/8/22)

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Relevance: High

Strength of Science: High

Research Timeline: Post Approval

Study : Mutations in BRCA1 or BRCA2 may increase risk for endometrial cancer

Most relevant for: People with BRCA1 or BRCA2 mutations

A Dutch study added further evidence that women with a BRCA1 mutation may have an elevated risk for endometrial cancer. The study found that the endometrial cancer in women with either a BRCA1 or BRCA2 mutation was more likely to be an aggressive form of cancer associated with a poor outcomes. (posted 11/30/21)

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Relevance: Medium-Low

Research Timeline: Human Research

Update : Blood tests called liquid biopsies for cancer screening, monitoring and treatment

Most relevant for: People considering a liquid biopsy to screen for cancer

Could a simple blood test change cancer detection, treatment and monitoring? Several companies are offering a type of blood test known as a liquid biopsy to detect multiple cancers at their earliest stages, monitor response to treatment and help choose the best treatment. Although progress has been made using liquid biopsies to treat cancer, these tests have not yet been shown to detect cancer early enough to save lives. (posted 9/29/21)

Este artículo está disponible en español.

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Relevance: Medium

Strength of Science: Medium-High

Research Timeline: Post Approval

Study : Do sugared beverages increase the risk of early-onset colorectal cancer?

Most relevant for: Healthy people with an average colorectal cancer risk

A study of female nurses in the U.S. suggests that a high intake of sugar-sweetened beverages may increase the risk of colorectal cancer before age 50. However, researchers saw few early-onset colorectal cancer cases which limited the findings. (posted 9/21/21)

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Relevance: High

Strength of Science: High

Research Timeline: Post Approval

Study : Cancer risks of people with inherited PALB2 mutations

Most relevant for: people with inherited PALB2 mutations

In the largest study of people with inherited PALB2 mutations to date, the gene was linked to increased lifetime risk of breast cancer in women and men, ovarian and pancreatic cancer but not prostate or colorectal cancer. (posted 7/1/21)

Este artículo está disponible en español.

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