PARP inhibitor treatment for metastatic prostate cancer shows most benefit in men with inherited BRCA mutations
https://www.facingourrisk.org/XRAY/niraparib-for-metastatic-prostate-cancer
Full article: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00757-9/fulltext
This study looked at the benefit of using the PARP inhibitor niraparib to treat metastatic castration-resistant prostate cancer (mCRPC). Participants included those with an inherited or tumor mutation in BRCA1 or BRCA2 or an inherited or tumor mutation in another gene that affects DNA repair. Participants with an inherited or tumor mutation in BRCA1 or BRCA2 had better survival compared to those without a BRCA mutation. Side effects from niraparib were common, and consistent with previous reports for PARP inhibitors. (posted 9/6/2022)
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Questions To Ask Your Health Care Provider
- Is genetic testing recommended for me?
- Does my prostate cancer have homologous recombination deficiency (HRD)?
- Is my prostate cancer metastatic?
- Is PARP inhibitor therapy appropriate for me?
Open Clinical Trials
The following studies look at PARP inhibitors and similar agents for treating people with advanced prostate cancer.
- NCT05932862: Study of a New InvestigationaI Inhibitor to Treat People with Advanced Solid Tumors. The study examines the safety and effectiveness of an investigational treatment XL309 when used alone or in combination with a PARP inhibitor to treat people with some advanced solid tumors including prostate cancer.
- NCT05005728: XmAb®20717 Alone or in Combination With Chemotherapy or Targeted Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer. This study looks at the safety and clinical activity of the drug XmAb20717 alone or in combination with standard-of-care anticancer therapies in patients with metastatic castration-resistant prostate cancer who have been treated with at least 2 prior lines of treatment.
- NCT05417594: Study of the PARP inhibitor AZD9574 Alone and Combined with Other Cancer Medicines to Treat People with Advanced Solid Cancers (CERTIS1 Study). This study looks at a new PARP inhibitor AZD9574 given alone and in combination with other anti-cancer drugs in people with advanced cancer that has come back or progressed.
Other clinical trials for people with prostate cancer can be found here.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.