Mutations in Lynch syndrome genes MSH6 and PMS2 may be associated with breast cancer
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Some women with mutations in MSH6 and PMS2, two Lynch syndrome genes, may have a modest (2 to 3-fold) increased risk for breast cancer. (6/14/18 updated 09/25/19)

Expert Guidelines

The National Comprehensive Cancer Network (NCCN) is a national panel of experts that create guidelines for cancer treatment. NCCN has recommendations for screening in people with a gene mutation associated with Lynch Syndrome:

Guidelines for women

Guidelines for men and women

Questions To Ask Your Health Care Provider

Open Clinical Trials


FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.