Cancer risk associated with inherited mutations in Lynch syndrome genes
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Lynch syndrome is the most common inherited cause of cancer affecting about 1 in 300 people. People with Lynch syndrome have an increased risk of colorectal endometrial and other cancers. A large study followed people with mutations in the Lynch syndrome genes MLH1, MSH2, MSH6 and PMS2 to determine the risk of other types of cancer. (2/21/20)

Expert Guidelines

Guidelines for risk management of Lynch syndrome

The National Comprehensive Cancer Network (NCCN) has guidelines for cancer risk management in people with a Lynch syndrome mutation. 

Guidelines for men and women

Additional guidelines for women

Pancreatic cancer

Risk to relatives

Questions To Ask Your Health Care Provider

Open Clinical Trials

The following studies are enrolling people with a mutation linked to Lynch syndrome:


FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.