Some people with recurrent ovarian cancer have long-lasting benefit from PARP inhibitors
https://www.facingourrisk.org/XRAY/long-term-response-parp-inhibitors-ovarian-cancer
Full article: https://jamanetwork.com/journals/jamaoncology/fullarticle/2850880
PARP inhibitors are medicines used for some people with ovarian cancer as maintenance therapy after treatment. A new study looked at people whose cancer did not worsen for at least 5 years after starting a PARP inhibitor. Researchers called this an “exceptional response.” (posted 09/19/2026)
By: Piri Welcsh, PhD
Reviewed by: Katherine Pennington, MD
Questions To Ask Your Health Care Provider
- Am I considered an exceptional responder to PARP inhibitor treatment?
- How long do you recommend that I continue my PARP inhibitor, and why?
- What are the risks and benefits of continuing treatment or stopping treatment?
- If I stop my PARP inhibitor, how often will I need follow-up visits, blood tests and scans
- What symptoms or blood test changes might suggest a serious side effect, such as a bone marrow problem?
- If my cancer comes back after a long response, what treatment options or clinical trials should I consider?
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.