Hormone therapy and breast cancer risk after ovary removal in women with a BRCA1 mutation
https://www.facingourrisk.org/XRAY/hormone-therapy-after-ovarian-removal
Full article: https://jamanetwork.com/journals/jamaoncology/article-abstract/2678466
Does hormone therapy (HT) alter the risk of breast cancer for woman carrying a BRCA1 mutation who have never been diagnosed with cancer? In this study, researchers showed that among women with BRCA1 mutations, HT use did not increase breast cancer rates for 10 years after ovary removal. More women taking combined estrogen plus progesterone developed breast cancer compared to those taking estrogen only, though this difference was not statistically significant. (9/7/18)
Questions To Ask Your Health Care Provider
- Should I consider using HT after risk-reducing ovary removal? After menopause?
- What kind of HT would be most appropriate for me?
- What are other options for managing menopause without HT?
- What risks are associated with taking or not taking HT after removal of my ovaries?
- Can you refer me to a menopause expert?
Open Clinical Trials
The following are studies on menopause and menopause management for survivors and previvors:
- NCT04439370: Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women. This study will look at the effects of early menopause on blood pressure.
- NCT03572153: A Mind-Body Intervention for Hot Flash Management. The main goal of this study is to test whether self-administered hypnosis can be used to reduce hot flashes more than self-administered white noise hypnosis over 6 weeks of home practice.
- NCT04821141: Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens. Women at increased risk for breast cancer who experience hot flashes will receive bazedoxifene plus conjugated estrogens (similar to the drug Duavee) for 6 months or a control (no drug). Researchers will measure breast density with mammography and needle biopsy that looks at biomarkers.
- NCT06112756: A Study to Learn About How Elinzanetant Works and How Safe it is in Women Having Sleep Disturbances Associated with Menopause (NIRVANA). The study treatment Elinzanetant is being studied to treat symptoms like hot flashes which are caused by hormonal changes associated with menopause. It may block the activity of a protein that has been found to contribute to sleep disturbances.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.