Understanding inherited PALB2 mutations and risk of multiple cancers
https://www.facingourrisk.org/XRAY/PALB2-mutations-multiple-cancers
Full article: https://www.abstractsonline.com/pp8/#!/21392/presentation/143
Inherited mutations in the PALB2 gene are linked to increased risk of several cancers, including breast, pancreatic, ovarian, and prostate cancers. This study estimates the effect of an inherited PALB2 mutation on a person’s risk of developing each of these cancers. (posted 4/6/2026)
Questions To Ask Your Health Care Provider
- I have a cancer diagnosis. Do you recommend genetic testing?
- If I test positive for an inherited mutation, will that change my treatment recommendations?
- If I test positive for an inherited mutation, what does it mean for my children, siblings, or other family members?
- I have a PALB2 gene mutation. Which cancers should I be screened for, and how often should I be screened?
- For breast cancer screening, is a mammogram still the right screening for me, or should I consider an MRI?
- What kind of screenings are available for other cancers, and do they have an impact on health outcomes?
- If I test positive for PALB2, do you recommend that my relatives be tested too?
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.