FDA recommends testing to prevent serious side effects from 5-FU and capecitabine chemotherapy
https://www.facingourrisk.org/XRAY/DPYD-genetic-testing-recommended-for-chemotherapy-treatment
Full article: https://www.fda.gov/drugs/resources-information-approved-drugs/safety-labeling-update-capecitabine-and-fluorouracil-5-fu-risks-associated-dihydropyrimidine
A small number of people treated with the chemotherapy drugs 5-FU (5-fluorouracil) or capecitabine (Xeloda) can have serious or even life-threatening side effects because their body breaks down the drug more slowly than is typical. A genetic test called DPYD testing can help identify people at higher risk for serious side effects before treatment starts. (posted 2/11/26)
Questions To Ask Your Health Care Provider
- Does my treatment plan include 5-FU or capecitabine?
- If you recommend these drugs, should I have DPYD testing before I start treatment?
- How long will it take to get test results?
- Is there any concern about delaying the start of my chemotherapy to have DPYD testing?
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.