Genes, genetic counseling and disparities in endometrial cancer
Full article: https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.35071
Endometrial cancer is on the rise, and it can run in families. Genetic counseling has benefits for people with cancer and their family members. However, Black women with endometrial cancer more often have worse outcomes than white women. Black women with endometrial cancer who test positive for an inherited mutation are less likely to see a genetic counselor. Given these disparities, Black women would benefit from better access to and referrals for genetic counseling. (Posted 12/14/23)
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Questions To Ask Your Health Care Provider
- For people with endometrial cancer:
- Do you recommend genetic testing? Why or why not?
- Have you tested my cancer for genetic mutations? If yes, what are the results of these tests?
- For people who are at increased risk of endometrial cancer:
- Which cancer screenings do you recommend for me—at what age and how often?
- Can I get tested for inherited mutations linked to cancer because my family member(s) had cancer?
Open Clinical Trials
The following organizations have resources related to endometrial cancer.
The National Comprehensive Cancer Network (NCCN) has guidelines for genetic counseling and testing for people diagnosed with colorectal or endometrial cancer. People who have any of the following should speak with a genetics expert about genetic testing:
- A tumor test result that suggests an inherited mutation (for example, an MSI-H or dMMR tumor).
- A blood relative who tested positive for an inherited mutation linked to cancer.
- Colorectal or endometrial cancer diagnosed before age 50.
- Diagnoses of more than one cancer.
- A family history of one or more first- or second-degree relatives with any of the following types of cancer diagnosed before age 50 or two or more first- or second-degree relatives with any of the following cancers diagnosed at any age:
- small bowel
- biliary tract
- brain (usually glioblastoma)
- Colorectal cancer and a personal history of polyps:
- 10 or more adenomatous polyps
- 2 or more hamartomatous polyps
- 5 or more serrated polyps close to the rectum
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.