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FORCE Publications

Research on Diet and Exercise in Ovarian Cancer

New Research Study Focuses on Exercise in Ovarian Cancer Survivors

Emerging research suggests that exercise and weight control can play a role in breast cancer survival. But similar studies for ovarian cancer survival have not yet been done. A new study from the Gynecologic Oncology Group — a cooperative organization of the National Cancer Institute — will investigate whether women treated for ovarian cancer benefit from a program to control diet, nutrition, and weight. The study is called LIVES (Lifestyle Intervention for
oVarian cancer Enhanced Survival) and is also known as GOG 0225. Researchers hope to recruit over 1,000 women at study sites around the United States. The study is open to women who:

  • have ovarian, primary peritoneal, or fallopian tube cancer in stages Stage II, III, or IV;
  • have completed all primary chemotherapy and consolidation therapy (if administered) between six weeks and four months prior to enrollment;
  • are in complete remission;
  • have achieved a documented complete response (no clinical evidence of persistent or recurrent disease) to treatment based on a normal CA-125 test and CT scan.

Participants will be randomized to one of two groups. One group will receive a diet and physical activity plan to control weight and increase activity. Participants in this group will also receive educational materials and coaching on reading food labels, and frequent lifestyle coaching by telephone. These women will also maintain a fat gram diary and a step diary at least three times a week. The other group will receive educational materials and telephone contact every six months. Blood tests of a subset of participants will be performed at the beginning of the study and at 6-, 12-, and 24- month intervals.

Visit the study website or clinicaltrials.gov for more information and a list of study sites.

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